C6 antibody | 056B-

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Mouse anti Human C6

Product Type
Monoclonal Antibody
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
MCA2666 C E F 0.1 mg
Mouse anti Human C6 antibody, clone 056B- recognises complement component 6 (C6), a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C-terminus of the C5b alpha-chain, anchoring the molecule to the membrane; they also binds complement component 7. This enables the formation of the C5b–7 precursor complex. C5b–7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.

Mouse anti Human C6 antibody, clone 056B- recognises C6 as a component of the MAC.

Product Details

Target Species
Product Form
Purified IgG - liquid
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Borate buffered saline
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
Purified human C6.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml

Storage Information

Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guaranteed until date of expiry. Please see product label.

More Information

P13671 Related reagents
Entrez Gene
C6 Related reagents
GO Terms
GO:0005515 protein binding
GO:0005579 membrane attack complex
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
GO:0045087 innate immune response
For research purposes only

Applications of C6 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Kidney from post streptococcal glomerulonephritis patients

Negative Isotype Controls Available

Description Product Code Pack Size Applications List Price Quantity
Mouse IgG1 Negative Control MCA928 100 Tests F

Useful Reagents Available

Description Product Code Pack Size Applications List Price Quantity
Histar Detection System STAR3000A 50 Tests C P
Histar Detection System STAR3000B 150 Tests C P
Histar Detection System STAR3000C 500 Tests C P

Product Specific References

References for C6 antibody

  1. DiScipio, R.G. et al. (1999) Function of the factor I modules (FIMS) of human complement component C6.
    J Biol Chem. 274 (45): 31811-8.
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