C4c antibody | 033D-69.4.1 (10-12)
Mouse anti Human C4c
- Product Type
- Monoclonal Antibody
- 033D-69.4.1 (10-12)
|Mouse anti Human C4c antibody, clone 033D-69.4.1 (10-12) recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kDa) and alpha 3 (25 kDa) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma.|
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3)
- Purified human C4c.
- Approx. Protein Concentrations
- Current, batch-specific concentration 1.15 mg/ml
- For research purposes only
- Guaranteed until date of expiry. Please see product label.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- 1Clone 10-12 binds both C4c and C4 and so is not suitable for all ELISA applications.
- Histology Positive Control Tissue
- Kidney sections from post-streptococcal glomerulonephritis patients.
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Mouse IgG1 Negative Control||MCA928||F||100 Tests||Log in|
|List Price||Your Price|
|Description||Mouse IgG1 Negative Control|
Press, E.M. & Gagnon, J. (1981) Human complement component C4. Structural studies on the fragments derived from C4b by cleavage with C3b inactivator.
Biochem J. 199 (2): 351-7.
Leung, E. et al. (2006) The complement regulator C4b-binding protein (C4BP) interacts with both the C4c and C4dg subfragments of the parent C4b ligand: evidence for synergy in C4BP subsite binding.
Biochemistry. 45 (27): 8378-92.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"View all Anti-Human Products
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