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BLTR antibody | 202/7B1

Product Code Applications Pack Size List Price Your Price Qty
MCA2108
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IF IY 0.2 mg loader
List Price Your Price
loader
MCA2108GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IF IY 0.1 mg loader
List Price Your Price
loader

Mouse anti Human BLTR antibody, clone 202/7B1 recognizes Human leukotriene B4 receptor, also known as BLTR, Chemoattractant receptor-like 1, G-protein coupled receptor 16 or P2Y purinoceptor 7. BLTR is a 353 ~40 kDa multipass transmembrane glycoprotein

BLTR is expressed by peripheral blood granulocytes and is important in the pro-inflammatory response.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
MCA2108: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
MCA2108GA: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Yes
Immunogen
HeLa cell transfectants expressing human BLTR.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/50 Pack Size: 0.2 mg
1/100 Pack Size: 0.1 mg
1/100 Pack Size: 0.2 mg
1/200 Pack Size: 0.1 mg
Immunoassay
Immunofluorescence
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells or 100μl whole blood

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Description Mouse IgG2a Negative Control

Source Reference

  1. Pettersson, A. et al. (2000) First-generation monoclonal antibodies identifying the human leukotriene B(4) receptor-1.
    Biochem Biophys Res Commun. 279 (2): 520-5.

References for BLTR antibody

  1. Sabirsh, A. et al. (2005) Fluorescent leukotriene B4: potential applications.
    J Lipid Res. 46: 1339-46.
  2. Heller, E.A. et al. (2005) Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
    Circulation. 112: 578-86.
  3. Medoff, B.D. et al. (2005) BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation.
    J Exp Med. 202: 97-110.
  4. Islam, S.A. et al. (2006) The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans.
    Blood. 107: 444-53.
  5. Thomas, S.Y. et al. (2007) Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway.
    J Immunol. 179: 1901-12.
  6. Serezani, C.H. et al. (2009) FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.
    Blood. 114: 3316-24.
  7. Costa, M.F. et al. (2010) Leukotriene B4 mediates gammadelta T lymphocyte migration in response to diverse stimuli.
    J Leukoc Biol. 87: 323-32.
  8. Laarman, A.J. et al. (2012) Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis.
    EMBO J. 31: 3607-19.
  9. View The Latest Product References
  10. Wang, L. et al. (2012) BLT1-Dependent Alveolar Recruitment of CD4+CD25+ Foxp3+ Regulatory T Cells is Important for Resolution of Acute Lung Injury.
    Am J Respir Crit Care Med.186: 989-98.
  11. Loell, I. et al. (2012) Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis.
    Ann Rheum Dis. 72: 293-9.
  12. Dixit, N. et al. (2014) Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis.
    Arthritis Res Ther. 16: 496.
  13. Sezin, T. et al. (2019) Dual inhibition of complement factor 5 and leukotriene B4 synergistically suppresses murine pemphigoid disease.
    JCI Insight. 4 (15)Aug 08 [Epub ahead of print].
  14. Askarian, F. et al. (2021) The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa. virulence in systemic infection.
    Nat Commun. 12 (1): 1230.
  15. Williams, K.M. et al. (2022) Prospective Phase II Trial of Montelukast to Treat Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation and Investigation into Bronchiolitis Obliterans Syndrome Pathogenesis.
    Transplant Cell Ther. S2666-6367(22)00049-5.

Synonyms
Leukotriene B4 Receptor
RRID
AB_323834
UniProt
Q15722
Entrez Gene
LTB4R
GO Terms
GO:0000166 nucleotide binding
GO:0006936 muscle contraction
GO:0005887 integral to plasma membrane
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

MCA2108

159662 1702

MCA2108GA

1705

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