Atrial Natriuretic Peptide antibody | 23/1
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Mouse anti Human Atrial Natriuretic Peptide
- Product Type
- Monoclonal Antibody
- Clone
- 23/1
- Isotype
- IgG1
- Specificity
- Atrial Natriuretic Peptide
Antibody Quality and Performance Guarantee
| Mouse anti Human Atrial Natriuretic Peptide antibody, clone 23/1 Recognizes noth the whole human atrial natriuretic peptide and the c terminal fragment (amino acids 4-28). ANP is formed by the cleavage of the holo Natriuretic peptides A by CORIN to release functionally active ANP. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide corresponding to part of the native molecule conjugated to bovine serum albumin.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
||
| Radioimmunoassays | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Competitive radioimmunoassay (clinical measurement of circulating ANP levels, possibly in conjunction with cyclic GMP). Liquid phase assay without plasma extraction.
Competitive radioimmunoassay (clinical measurement of circulating ANP levels, possibly in conjunction with cyclic GMP). Liquid phase assay without plasma extraction.
References for Atrial Natriuretic Peptide antibody
-
Shan, X. et al. (2008) Apoptosis signal-regulating kinase 1 attenuates atrial natriuretic peptide secretion.
Biochemistry. 47: 10041-8. -
Chen, J.H. et al. (2012) Pathophysiology of sudden cardiac death as demonstrated by molecular pathology of natriuretic peptides in the myocardium.
Forensic Sci Int. 223 (1-3): 342-8.
- Synonyms
- ANP
- RRID
- AB_620041
- UniProt
- P01160
- Entrez Gene
- NPPA
- GO Terms
- GO:0005576 extracellular region
- GO:0005179 hormone activity
- GO:0006182 cGMP biosynthetic process
- GO:0007168 receptor guanylyl cyclase signaling pathway
- GO:0008217 regulation of blood pressure
- GO:0050880 regulation of blood vessel size
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