Mouse anti Human apolipoprotein H antibody, clone ID2
recognizes the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1, APC inhibitor, activated protein C-binding protein or anticardiolipin cofactor. Apolipoprotein H is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, a process involved in the pathogenesis of recurrent miscarriage and thrombotic tendencies due to antiphospholipid syndrome
- Target Species
- Product Form
- Tissue Culture Supernatant - liquid
- Preservative Stabilisers
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
negative regulation of endothelial cell proliferation
triglyceride metabolic process
blood coagulation, intrinsic pathway
negative regulation of endothelial cell migration
negative regulation of angiogenesis
negative regulation of blood coagulation
negative regulation of myeloid cell apoptosis
very-low-density lipoprotein particle
high-density lipoprotein particle
negative regulation of smooth muscle cell apoptosis
eukaryotic cell surface binding
positive regulation of lipoprotein lipase activity
negative regulation of fibrinolysis
lipoprotein lipase activator activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Apolipoprotein H antibody
|Immunohistology - Frozen
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive control.
- Histology Positive Control Tissue
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Secondary Antibodies Available
Product Specific References
References for Apolipoprotein H antibody
Mak, I.Y. et al. (2002) Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro.
J Clin Endocrinol Metab. 87 (6): 2581-8.
Vlachoyiannopoulos, P.G. et al. (2004) Anti-CD40 antibodies in antiphospholipid syndrome and systemic lupus erythematosus.
Thromb Haemost. 92: 1303-11.
Lopez, D. et al. (2004) Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies to oxLig-1/beta2-glycoprotein I in patients with systemic lupus erythematosus and antiphospholipid syndrome.
Am J Clin Pathol. 121 (3): 426-36.
Goonetilleke, U.R. et al. (2012) Death is associated with complement C3 depletion in cerebrospinal fluid of patients with pneumococcal meningitis.
mBio. 3 (2)Mar 13 [Epub ahead of print].
Chamley, L.W. et al. (2001) Is interleukin-3 important in antiphospholipid antibody-mediated pregnancy failure?
Fertil Steril. 76 (4): 700-6.
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