Apolipoprotein H antibody | ID2
Mouse anti Human apolipoprotein H antibody, clone 1D2 recognises the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1, APC inhibitor, activated protein C-binding protein or anticardiolipin cofactor. Apolipoprotein H is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, a process involved in the pathogenesis of recurrent miscarriage and thrombotic tendencies due to antiphospholipid syndrome.
- Target Species
- Product Form
- Tissue Culture Supernatant - liquid
- Preservative Stabilisers
0.09% Sodium Azide
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 18 months from date of despatch.
- P02749 Related reagents
- Entrez Gene
- APOH Related reagents
- GO Terms
- GO:0001937 negative regulation of endothelial cell proliferation
- GO:0001948 glycoprotein binding
- GO:0005543 phospholipid binding
- GO:0006641 triglyceride metabolic process
- GO:0007597 blood coagulation, intrinsic pathway
- GO:0008201 heparin binding
- GO:0009986 cell surface
- GO:0010596 negative regulation of endothelial cell migration
- GO:0016525 negative regulation of angiogenesis
- GO:0030195 negative regulation of blood coagulation
- GO:0031639 plasminogen activation
- GO:0033033 negative regulation of myeloid cell apoptosis
- GO:0034197 triglyceride transport
- GO:0034361 very-low-density lipoprotein particle
- GO:0034364 high-density lipoprotein particle
- GO:0034392 negative regulation of smooth muscle cell apoptosis
- GO:0042627 chylomicron
- GO:0043499 eukaryotic cell surface binding
- GO:0051006 positive regulation of lipoprotein lipase activity
- GO:0051918 negative regulation of fibrinolysis
- GO:0060230 lipoprotein lipase activator activity
- For research purposes only
Applications of Apolipoprotein H antibody
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive control.
- Histology Positive Control Tissue
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for Apolipoprotein H antibody
Mak, I.Y. et al. (2002) Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro.
J Clin Endocrinol Metab. 87 (6): 2581-8.
Vlachoyiannopoulos, P.G. et al. (2004) Anti-CD40 antibodies in antiphospholipid syndrome and systemic lupus erythematosus.
Thromb Haemost. 92: 1303-11.
Goonetilleke, U.R. et al. (2012) Death Is Associated with Complement C3 Depletion in Cerebrospinal Fluid of Patients with Pneumococcal Meningitis
mBio 3: e00272-11
Lopez, D. et al. (2004) Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies to oxLig-1/beta2-glycoprotein I in patients with systemic lupus erythematosus and antiphospholipid syndrome.
Am J Clin Pathol. 121 (3): 426-36.
Chamley, L.W. et al. (2001) Is interleukin-3 important in antiphospholipid antibody-mediated pregnancy failure?
Fertil Steril. 76 (4): 700-6.