Amylin antibody | R10/99



Product Details
- Target Species
- Human
- Product Form
- Tissue Culture Supernatant - liquid
- Buffer Solution
- 0.1M TRIS
- Preservative Stabilisers
- Pack Size: 0.25 ml0.09% Sodium Azide (NaN3)Pack Size: 2 ml
0.09% Sodium Azide - Immunogen
- A peptide CATQRLANFLV corresponding to residues 40-50 of human IAPP coupled to tuberculin.
- Fusion Partners
- Spleen cells from immunized a BALB/c mouse were fused with cells of the mouse SP2/0 myeloma cell line.
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P10997
- Entrez Gene
- IAPP
- GO Terms
- GO:0006915 apoptosis
- GO:0005576 extracellular region
- GO:0007165 signal transduction
- GO:0005179 hormone activity
- GO:0005625 soluble fraction
- GO:0007267 cell-cell signaling
- GO:0031018 endocrine pancreas development
- Regulatory
- For research purposes only
Applications of Amylin antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunofluorescence | |||
Immunohistology - Frozen | 1/100 | ||
Immunohistology - Paraffin | 1/100 |
- Immunohistology
- This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Secondary Antibodies Available
Product Specific References
References for Amylin antibody
-
Gong, W. et al. (2007) Amylin deposition in the kidney of patients with diabetic nephropathy.
Kidney Int. 72 (2): 213-8. -
Bhattacharya, S. et al. (2007) Cloning and expression of human islet amyloid polypeptide in cultured cells.
Biochem Biophys Res Commun. 356: 622-8. -
Gurlo, T. et al. (2010) Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.
Am J Pathol. 176: 861-9. -
Zhao, H. et al. (2010) Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition.
Pancreas. 39: 843-6. -
Nakamura, S. et al. (2008) Transthyretin amyloidosis and two other aging-related amyloidoses in an aged vervet monkey.
Vet Pathol. 45: 67-72. -
Zhao, H.L. et al. (2009) Amyloid oligomers in diabetic and nondiabetic human pancreas.
Transl Res. 153: 24-32. -
Campbell-Thompson, M.L. et al. (2012) Staining protocols for human pancreatic islets.
J Vis Exp. 63: e4068. -
Zhang, X. et al. (2011) Conformation-dependent scFv antibodies specifically recognize the oligomers assembled from various amyloids and show colocalization of amyloid fibrils with oligomers in patients with amyloidoses.
Biochim Biophys Acta. 1814 (12): 1703-12. -
Ramos-Vera, J.A. et al. (2016) Advanced Diagnostic Techniques
In: Canine and Feline Cytology - E-Book: A Color Atlas and Interpretation Guide -
Lee, J. et al. (2013) Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.
Elife. 2: e00940. -
Zhang, X.X. et al. (2018) Human amylin induces CD4+Foxp3+ regulatory T cells in the protection from autoimmune diabetes.
Immunol Res. 66 (1): 179-86.
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