Alpha A Crystallin antibody | c9F2

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WB ResetMouse anti Human Alpha A Crystallin
- Product Type
- Monoclonal Antibody
- Clone
- c9F2
- Isotype
- IgG1
- Specificity
- Alpha A Crystallin
Mouse anti Human Alpha A Crystallin antibody, clone c9F2 recognizes alpha A crystallin, a 20 kDa water-soluble major structural protein and member of the heat shock protein family, designated HSPB4, which acts as a molecular chaperone and is believed to play a role in the maintenance of ocular lens transparency/refractive index. Besides the involvement of both alpha A and alpha B crystallin in the prevention of protein precipitation and cataract formation in the eye, alpha crystallins have also been demonstrated in other tissues including the heart, brain, kidney, spleen and thymus. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
10% Glycerol - Immunogen
- E. coli-derived recombinant protein corresponding to full-length (aa1-173) human crystallin alpha A.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the mouse Sp2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
||
Western Blotting | ![]() |
1/1000 | 1/2000 |
Further Reading
-
Andley UP et al. (1996) Cloning, expression, and chaperone-like activity of human alphaA-crystallin.
J Biol Chem. 271 (50): 31973-80.
- RRID
- AB_906002
- UniProt
- P02489
- Entrez Gene
- CRYAA
- GO Terms
- GO:0051082 unfolded protein binding
- GO:0005212 structural constituent of eye lens
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0006916 anti-apoptosis
- GO:0007601 visual perception
- GO:0009408 response to heat
- GO:0032387 negative regulation of intracellular transport
- GO:0051260 protein homooligomerization
- View More GO Terms
MCA2696

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