CD184 / CXCR4 antibody | 9D9
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|Mouse anti Chicken CD184 / CXCR4 clone 9D9, recognizes the chicken homologue of human CD184, also known as CXCR4 (C-X-C Receptor type 4) and fusin.
CXCR4 is a receptor for the chemokine, stromal-derived factor-1 (SDF-1), also known as CXCL12. Research has demonstrated that in chicks CXCR4 is expressed by cardiac neural crest cells and together with SDF-1 is involved with the migration of cells and development of the heart. Where CXCR4 function is lost, cell migration is impaired resulting in cell death and misexpression of SDF-1 leading to cardiovascular defects (Escot et al.. 2013). CXCR4 expression is also linked with other development processes including cerebellar development and with vascularization of the gastrointestinal tract. Clone 9D9 provides a useful antibody for studying development biological processes.
Bursa cells may be used as a positive control for CXCR4 in flow cytometry.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Chicken CXCR4 (chCXCR4) transfected HEK294 cells
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul
References for CD184 / CXCR4 antibody
Escot, S. et al. (2013) Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects.
Circ Res. 113: 505-16.
Kaiser, P. et al. (2005) A genomic analysis of chicken cytokines and chemokines.
J Interferon Cytokine Res. 25: 467-84.
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