Interleukin 4 (IL-4) is a cytokine primarily secreted by Th2 cells, basophils, eosinophils, and mast cells. It plays an important role in downregulating Th1 mediated responses.
IL-4 exhibits sequence homology with IL-13 that results in receptor and intracellular signal cascade sharing. It is best known for its role as one of the cytokines that defines the Th2 phenotype in lymphocytes. Its key effects on the immune system are contributing to regulating cell proliferation and apoptosis. Further downstream functions are modulation of gene expression in macrophages, lymphocytes, fibroblasts, epithelial and endothelial cells. Th2 derived IL-4 upregulates the production of the immunomodulatory cytokine IL-10 in Th1 cells, which reduces the pathogenicity of Th1 cells.
Recent research underlines the importance of the immune function relevance of IL-4:
Find our anti-IL-4 antibodies and associated protein controls for your Th2 immune response experiments listed below; links to experimental data and peer reviewed publications can be found on each datasheet.