Interleukin 6 (IL-6) is a cytokine with dual functionality, predominantly pro-inflammatory but also anti-inflammatory. The IL-6 family includes IL-27, IL-31, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary inhibitory factor (CNTF), cardiotropin-1 (CT-1), cardiotrophin-like related cytokine and stimulating neurotrophin-1/B-cell stimulating factor 3 (NNT-1), and neuropoietin (NPN).
IL-6 has two receptor versions; the membrane bound IL-6 receptor (IL-6R) is made up of CD126 and the universally expressed gp130 (CD130). Only a few cell types have CD126 expression: hepatocytes, leukocytes and megakaryocytes. The soluble form of IL-6R captures IL-6, then binds cell surface expressed gp130. Signaling via the membrane bound IL-6R is called "classical", while the soluble stimulation pathway is referred to as trans-signaling. It has been suggested that the latter is associated with inflammatory processes.
Recent research underlines the importance of IL-6 to bovine immunity and as an animal model for infectious diseases; the prime application for IL-6 analyses is ELISA:
Find our anti-IL-6 antibodies and associated protein controls for your ELISA assays listed below; links to experimental data and peer-reviewed publications can be found on each datasheet.