IL-5 antibody | TRFK5
|Rat anti mouse IL-5, clone TRFK5 recognizes mouse interleukin-5. IL-5 is a regulatory cytokine that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Rat anti mouse IL-5, clone TRFK5 may be used to neutralize IL-5 bioactivity in a functional assay (Schumacher. et al. 1988) and Abrams et al. 1992).
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Human Pig Guinea Pig
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Purified natural murine IL-5
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Flow Cytometry 1|
- 1 Membrane permeabilisation is required for this application. The use of Leucoperm (Product Code BUF09) is recommended for this purpose.
References for IL-5 antibody
Schumacher, J.H. et al. (1988) The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.
J Immunol. 141 (5): 1576-81.
Abrams, J.S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Immunol Rev. 127: 5-24.
Röcken, M. et al. (1992) Central role for TCR/CD3 ligation in the differentiation of CD4+ T cells toward A Th1 or Th2 functional phenotype.
J Immunol. 148 (1): 47-54.
Betz, M. & Fox, B.S. (1990) Regulation and development of cytochrome c-specific IL-4-producing T cells.
J Immunol. 145 (4): 1046-52.
Akdis, C.A. et al. (1996) Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro.
J Clin Invest. 98 (7): 1676-83.
Portanova, J.P. et al. (1995) Rapid and selective induction of blood eosinophilia in guinea pigs by recombinant human interleukin 5.
Cytokine. 7 (8): 775-83.
- Entrez Gene
- GO Terms
- GO:0005125 cytokine activity
- GO:0005615 extracellular space
- GO:0006955 immune response
- GO:0008083 growth factor activity
- GO:0043193 positive regulation of gene-specific transcription
- GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
- GO:0051024 positive regulation of immunoglobulin secretion
- GO:0051091 positive regulation of transcription factor activity
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