CD34 antibody | MEC14.7
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|Rat anti Mouse CD34 antibody, clone MEC14.7 recognizes the murine CD34 cell surface antigen, which is expressed by endothelial cells and by haematopoietic stem cells. This antibody recognizes a neuraminidase sensitive epitope. As in the human system, CD34 antibodies in the mouse demonstrate slightly different staining patterns depending on their fine specificity. Rat anti Mouse CD34 antibody, clone MEC14.7 appears to recognize a subset of the stem cell population recognized by clone RAM34, and it is thought that this is due to differences in the epitope recognized by the two antibodies.|
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- T-end.1, a pMT transformed endothelial cell line.
- Approx. Protein Concentrations
- Pack Size: 0.25 mg, 25 µgIgG concentration 1.0 mg/mlPack Size: 0.1 mgIgG concentration 1 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Flow Cytometry||1/10 Pack Size: 0.25 mg, 25 µg
1/25 Pack Size: 0.1 mg
|1/20 Pack Size: 0.25 mg, 25 µg
1/50 Pack Size: 0.1 mg
|Immunohistology - Paraffin||1/20||1/200|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Garlanda, C. et al. (1997) Characterization of MEC 14.7, a new monoclonal antibody recognizing mouse CD34: a useful reage for identifying and characterizing blood vessels and hematopoietic precursors.
Eur J Cell Biol. 73 (4): 368-77.
References for CD34 antibody
Winding, B. et al. (2002) Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.
Clin Cancer Res. 8 (6): 1932-9.
Nguyen, L. et al. (2012) Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments.
BMC Cancer. 12: 522.
Morison, N.B. et al. (2007) The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women.
Reproduction. 133: 309-21.
Chen, L. et al. (2010) Roles of tetrahydrobiopterin in promoting tumor angiogenesis.
Am J Pathol. 177: 2671-80.
Ager, E.I. et al. (2010) Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases.
Cancer Cell Int. 10: 19
Chabot, S. et al. (2011) A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor.
J Exp Med. 208: 973-86.
Chen, J. et al. (2011) Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage.
Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E62-71.
Chen, J. et al. (2012) Transfusion of CXCR4-primed endothelial progenitor cells reduces cerebral ischemic damage and promotes repair in db/db diabetic mice.
PLoS One. 7 (11): e50105.
View The Latest Product References
Ouji, Y. & Yoshikawa, M. (2016) Maintenance of Skin Epithelial Stem Cells by Wnt-3a In Vitro.
Methods Mol Biol. 1516: 279-88.
Nguyen, L. et al. (2016) Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis.
BMC Cancer. 16 (1): 533.
Vávrová, J. et al. (2012) Irradiated stem cells and ageing of the haematopoietic system.
Radiat Environ Biophys. 51 (2): 205-13.
DaCosta, P.L.N. et al. (2018) The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model.
BMC Cancer. 18 (1): 382.
Danielyan, L. et al.. (2020) Cell motility and migration as determinants of stem cell efficacy
Rackham, C.L. et al. (2013) Maintenance of islet morphology is beneficial for transplantation outcome in diabetic mice.
PLoS One. 8 (2): e57844.
Fruchon, S. et al. (2012) Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis.
Leukemia. 26 (4): 795-805.
Zhu, C. et al. (2020) Antinociceptive effect of intrathecal injection of miR-9-5p modified mouse bone marrow mesenchymal stem cells on a mouse model of bone cancer pain.
J Neuroinflammation. 17 (1): 85.
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