CD200 antibody | OX-90
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|Rat anti Mouse CD200 antibody, clone OX-90 recognizes the mouse CD200 cell surface antigen, also known as OX2.
CD200 is expressed by splenic B lymphocytes, follicular dendritic cells, splenic endothelium and by neurons.
The CD200 - CD200 ligand system is of importance in the control of macrophage and granulocyte activation.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- Mouse CD200-rat CD4 fusion protein.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunised rats were fused with cells of the rat Y3 myeloma cell line
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
- Histology Positive Control Tissue
- Mouse spleen
References for CD200 antibody
Hoek, R.M. et al. (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200).
Science. 290 (5497): 1768-71.
Nathan, C. & Muller, W.A. (2001) Putting the brakes on innate immunity: a regulatory role for CD200?
Nat Immunol. 2 (1): 17-9.
Broderick, C. et al. (2002) Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis.
Am J Pathol. 161 (5): 1669-77.
Seeds, R.E. et al. (2011) The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon.
Int Immunopharmacol. 11 (7): 794-801.
Burger, P.E. et al. (2009) High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells.
Stem Cells. 27: 2220-8.
Garza, L.A. et al. (2011) Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells.
J Clin Invest. 121: 613-22.
Ko, Y.C. et al (2009) Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions.
J Anat. 214: 183-95.
Koning, N. et al. (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions.
J Neuropathol Exp Neurol. 68: 159-67.
View The Latest Product References
Krejsek, J. et al (2010) Expression of CD200/CD200R regulatory molecules on granulocytes and monocytes is modulated by cardiac surgical operation.
Perfusion. 25: 389-97.
Rijkers, E.S. (2007) Ligation of CD200R by CD200 is not required for normal murine myelopoiesis.
Eur J Haematol. 79: 410-6.
Rijkers, E.S. et al. (2008) The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes.
Mol Immunol. 45: 1126-35.
Liu, J.Q. et al. (2016) A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.
J Immunol. Jul 6. pii: 1600052. [Epub ahead of print]
Montiel, M. et al. (2016) Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus.
Antivir Chem Chemother. Aug 8. pii: 2040206616660851. [Epub ahead of print]
Liu, C. et al. (2018) The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation.
J Inflamm (Lond). 15: 28.
Tonecka, K. et al. (2021) The CD200 Regulates Inflammation in Mice Independently of TNF-α Production.
Int J Mol Sci. 22 (10)May 19 [Epub ahead of print].
Pannunzio, B. et al. (2022) CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury
Cells. 11 (11): 1786.
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