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CD3 antibody | CD3-12

Product Code Applications Pack Size List Price Your Price Qty
MCA1477
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F * IF P * WB 0.2 mg loader
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loader
MCA1477T
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SDS Safety Datasheet SDS
C F * IF P * 25 µg loader
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loader

Rat anti Human CD3 antibody, clone CD3-12 raised against a peptide representing an invariant cytoplasmic sequence within the CD3ε chain recognizes human CD3ε. CD3 is a multimeric protein complex composed of four distinct polypeptide chains (ε, γ, δ, ζ) that assemble and function as three pairs of dimers (εγ, εδ, ζζ). The CD3 complex serves as a T cell co-receptor that associates non-covalently with the T cell receptor (TCR) (Malissen 2008; Guy and Vignali 2009; Smith-Garvin et al. 2009). CD3 is a defining feature of cells belonging to the T cell lineage and can therefore be used as T cell marker.

As Rat anti Human CD3, clone CD3-12 has been raised against an epitope within the epsilon peptide chain, highly conserved among species clone CD3-12 has a very broad species crossreactivity for the CD3 marker. (Jones et al. 1993; Kothlow et al. 2005).
PrecisionAb Antibodies

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Bovine
Dog
Horse
Rhesus Monkey
Pig
Chicken
Mouse
Duck
Koala
Harbour Porpoise
Alpaca
Cynomolgus monkey
Spotted Hyena
Sea Lion
Cat
Amazon Parrot
Mammals Expected from Sequence
Birds Expected from Sequence
Raccoon
Great horned owl (Bubo virginianus)
Bullfrog
Xenopus
Amphibia Expected from Sequence
Rabbit
African green monkey
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
MCA1477: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
MCA1477T: Purified IgG prepared from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Yes
Immunogen
Synthetic peptide sequence derived from cytoplasmic epitope of CD3 (Glu-Arg-Pro-Pro-Pro-Val-Pro-Asn-Pro-Asp-Tyr-Glu-Pro-Cys) (ERPPPVPNPDYEPC )
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1 1/50 1/100
Immunofluorescence
Immunohistology - Frozen 1/100
Immunohistology - Paraffin 2 1/100
Western Blotting
  1. 1 Membrane permeabilization is required for this application. The use of Leucoperm (Product Code BUF09) is recommended for this purpose.
  2. 2This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Tris/EDTA buffer pH 9.0 is recommended for this purpose.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human tonsil

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Description Rat IgG1 Negative Control

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  109. Snyder, J.M. et al. (2020) Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.
    FASEB J. 34 (12): 15788-15804.
  110. Frost, S.H.L. et al. (2024) 211At-Labeled Anti-CD45 Antibody as a Nonmyeloablative Conditioning for Canine DLA-Haploidentical Stem Cell Transplantation
    Journal of Nuclear Medicine. 65 (9): 1443-9.

Further Reading

  1. Alterio de Goss, M. et al. (1998) Control of cytomegalovirus in bone marrow transplantation chimeras lacking the prevailing antigen-presenting molecule in recipient tissues rests primarily on recipient-derived CD8 T cells.
    J Virol. 72 (10): 7733-44.
  2. Burudi, E.M. et al. (2002) Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains.
    J Virol. 76 (23): 12233-41.
  3. Piriou-Guzylack, L. (2008) Membrane markers of the immune cells in swine: an update.
    Vet Res. 39: 54.

Immunofluorescence

Immunohistology - Frozen

Immunohistology - Paraffin

Western Blotting

RRID
AB_321245
UniProt
P07766
Entrez Gene
CD3E
GO Terms
GO:0004888 transmembrane receptor activity
GO:0005057 receptor signaling protein activity
GO:0005887 integral to plasma membrane
GO:0007172 signal complex assembly
GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0009897 external side of plasma membrane
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030159 receptor signaling complex scaffold activity
GO:0031295 T cell costimulation
GO:0042608 T cell receptor binding
GO:0046982 protein heterodimerization activity
GO:0050852 T cell receptor signaling pathway

MCA1477

149500A 149500D 155872 159344 162316 168618

MCA1477T

151891 158825 168115 168619

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