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CD3 antibody | CD3-12

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SDS Safety Datasheet SDS
C F * IF P * WB 0.2 mg loader
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Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F * IF P * 25 µg loader
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Rat anti Human CD3 antibody, clone CD3-12 raised against a peptide representing an invariant cytoplasmic sequence within the CD3ε chain recognizes human CD3ε. CD3 is a multimeric protein complex composed of four distinct polypeptide chains (ε, γ, δ, ζ) that assemble and function as three pairs of dimers (εγ, εδ, ζζ). The CD3 complex serves as a T cell co-receptor that associates non-covalently with the T cell receptor (TCR) (Malissen 2008; Guy and Vignali 2009; Smith-Garvin et al. 2009). CD3 is a defining feature of cells belonging to the T cell lineage and can therefore be used as T cell marker.

As Rat anti Human CD3, clone CD3-12 has been raised against an epitope within the epsilon peptide chain, highly conserved among species clone CD3-12 has a very broad species crossreactivity for the CD3 marker. (Jones et al. 1993; Kothlow et al. 2005).
PrecisionAb Antibodies

Target Species
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rhesus Monkey
Harbour Porpoise
Cynomolgus monkey
Spotted Hyena
Sea Lion
Amazon Parrot
Mammals Expected from Sequence
Birds Expected from Sequence
Great horned owl (Bubo virginianus)
Amphibia Expected from Sequence
African green monkey
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
MCA1477: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
MCA1477T: Purified IgG prepared from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Synthetic peptide sequence derived from cytoplasmic epitope of CD3 (Glu-Arg-Pro-Pro-Pro-Val-Pro-Asn-Pro-Asp-Tyr-Glu-Pro-Cys) (ERPPPVPNPDYEPC )
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
For research purposes only
12 months from date of despatch
PrecisionAb is a trademark of Bio-Rad Laboratories

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1 1/50 1/100
Immunohistology - Frozen 1/100
Immunohistology - Paraffin 2 1/100
Western Blotting
  1. 1 Membrane permeabilization is required for this application. The use of Leucoperm (Product Code BUF09) is recommended for this purpose.
  2. 2This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Tris/EDTA buffer pH 9.0 is recommended for this purpose.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human tonsil

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References for CD3 antibody

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  9. View The Latest Product References
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  97. Rütgen, B.C. et al. (2022) Composition of lymphocyte subpopulations in normal and mildly reactive peripheral lymph nodes in cats.
    J Feline Med Surg. 24 (2): 77-90.
  98. Cha, S. et al. (2023) Non-B, Non-T Acute Lymphoblastic Leukemia in a Cat
    Journal of Veterinary Clinics. 40 (4): 298-302.
  99. Yang, L. et al. (2018) Association of the expression of Th cytokines with peripheral CD4 and CD8 lymphocyte subsets after vaccination with FMD vaccine in Holstein young sires.
    Res Vet Sci. 119: 79-84.
  100. Sandersfeld, M. et al. (2024) Macrophage subpopulations in pediatric patients with lupus nephritis and other inflammatory diseases affecting the kidney.
    Arthritis Res Ther. 26 (1): 46.
  101. Vos, W.G. et al. (2024) T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation
    Frontiers in Immunology. 15 04 Mar [Epub ahead of print].
  102. Wyczanska, M. et al. (2024) Interleukin-10 enhances recruitment of immune cells in the neonatal mouse model of obstructive nephropathy.
    Sci Rep. 14 (1): 5495.
  103. Rütgen, B.C. et al. (2024) Flowcytometric data of intermediate-large cell gastrointestinal lymphoma presenting a gross mass in 32 cats – “let them glow in the flow”
    Frontiers in Veterinary Science. 28 May [Epub ahead of print].
  104. Yang, S.J. et al. (2022) Pancreatic islet-specific engineered T(regs) exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.
    Sci Transl Med. 14 (665): eabn1716.

Further Reading

  1. Alterio de Goss, M. et al. (1998) Control of cytomegalovirus in bone marrow transplantation chimeras lacking the prevailing antigen-presenting molecule in recipient tissues rests primarily on recipient-derived CD8 T cells.
    J Virol. 72 (10): 7733-44.
  2. Burudi, E.M. et al. (2002) Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains.
    J Virol. 76 (23): 12233-41.
  3. Piriou-Guzylack, L. (2008) Membrane markers of the immune cells in swine: an update.
    Vet Res. 39: 54.


Immunohistology - Frozen

Immunohistology - Paraffin

Western Blotting

Entrez Gene
GO Terms
GO:0004888 transmembrane receptor activity
GO:0005057 receptor signaling protein activity
GO:0005887 integral to plasma membrane
GO:0007172 signal complex assembly
GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0009897 external side of plasma membrane
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030159 receptor signaling complex scaffold activity
GO:0031295 T cell costimulation
GO:0042608 T cell receptor binding
GO:0046982 protein heterodimerization activity
GO:0050852 T cell receptor signaling pathway


149500A 149500D 155872 159344 162316 168618


151891 158825 168115 168619

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