PLVAP antibody | MECA-32
|Product Code||Applications||Pack Size||List Price||Your Price||Qty|
|Rat anti Mouse PLVAP antibody, clone MECA-32 recognizes murine plasmalemma vesicle-associated protein (PLVAP), a ~60 kDa protein also known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated.
In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3)
- Carrier Free
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from an immunized rat were fused with cells of the Sp2/0 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen||1/25||1/100|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
References for PLVAP antibody
Hallmann, R. et al. (1995) Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier.
Dev Dyn. 202 (4): 325-32.
Daneman, R. et al. (2010) Pericytes are required for blood-brain barrier integrity during embryogenesis.
Nature. 468 (7323): 562-6.
Okizaki SI et al. (2016) Vascular Endothelial Growth Factor Receptor Type 1 Signaling Prevents Delayed Wound Healing in Diabetes by Attenuating the Production of IL-1β by Recruited Macrophages.
Am J Pathol. Apr 13. pii: S0002-9440(16)30030-X. [Epub ahead of print]
Orford M et al. (2009) Generation of an ABCG2(GFPn-puro) transgenic line--a tool to study ABCG2 expression in mice.
Biochem Biophys Res Commun. 384 (2): 199-203.
Carson-Walter, E.B. et al. (2005) Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis.
Clin Cancer Res. 11 (21): 7643-50.
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