IL-17 antibody | TC11-18H10
Rat anti Mouse interleukin-17 antibody, clone TC11-18H10 recognises mouse Interleukin 17, a ~32 kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNF-alpha, IFN-gamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.
- Target Species
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- None present
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Guaranteed until date of expiry. Please see product label.
- For research purposes only
Applications of IL-17 antibody
|Application Name||Verified||Min Dilution||Max Dilution|
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
|Description||Product Code||Pack Size||Applications||List Price||Quantity|
|Goat anti Rat IgG:Alk. Phos. (Mouse Adsorbed)||STAR131A||1 ml||C E P WB|
|Goat anti Rat IgG:Biotin (Mouse Adsorbed)||STAR131B||0.5 mg||C E IF P WB|
|Rabbit F(ab')2 anti Rat IgG:Dylight®800||STAR16D800GA||0.1 mg||F IF WB|
|Rabbit F(ab')2 anti Rat IgG:FITC||STAR17B||1 mg||F|
|Rabbit F(ab')2 anti Rat IgG:HRP||STAR21B||1 mg||C E P RE|
|Goat F(ab')2 anti Rat IgG:FITC (Mouse Adsorbed)||STAR69||0.5 ml||F|
|Goat anti Rat IgG:DyLight®649 (Mouse Adsorbed)||STAR71D649GA||0.1 mg||F IF|
|Goat anti Rat IgG:Dylight®800 (Mouse Adsorbed)||STAR71D800GA||0.1 mg||F IF WB|
|Goat anti Rat IgG:HRP (Mouse Adsorbed)||STAR72||0.5 mg||C E P|
|Goat F(ab')2 anti Rat IgG:RPE (Mouse Adsorbed)||STAR73||0.5 ml||F|