CD71 antibody | YTA74.4
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Rat anti Mouse CD71
- Product Type
- Monoclonal Antibody
|Product Code||Applications||Pack Size||List Price||Your Price||Qty|
|Rat anti Mouse CD71 antibody, clone YTA74.4 recognizes the mouse Transferrin receptor protein 1 also known as CD71 or TfR1. CD71 is a 763 amino acid glycoprotein homodimer of ~95 kDa subunits. CD71 is expressed by dividing cells, and functions as a transferrin receptor mediating uptake of iron.
Rat anti Mouse CD71 antibody, clone YTA74.4 blocks the binding of R17 217.1.3. and R17 208.2 anti-TFR monoclonal antibodies (Trowbridge et al. 1982).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Concanavilin A activated mouse spleen cells.
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Fusion Partners
- Spleen cells from an immunised DA rat were fused with cells of the Y3/Ag1.2.3 rat myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 1 x 106 cells in 100μl
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Rat IgG2a Negative Control||MCA1212||E F||1 ml||Log in|
|List Price||Your Price|
|Description||Rat IgG2a Negative Control|
References for CD71 antibody
Millot, S. et al. (2010) Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation.
Blood. 116: 6072-81.
Kuo, Y.M. et al. (2004) Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse.
Gut. 53: 201-6.
Krysiak, K. et al. (2014) Reduced Levels of Hspa9 Attenuates Stat5 Activation in Mouse B-cells.
Exp Hematol. pii: S0301-472X(14)00817-0.
Byun, M. et al. (2007) Cowpox virus exploits the endoplasmic reticulum retention pathway to inhibit MHC class I transport to the cell surface.
Cell Host Microbe. 2: 306-15.
Ripich, T. and Jessberger, R. (2011) SWAP-70 regulates erythropoiesis by controlling α4 integrin.
Haematologica. 96: 1743-52.
Hadziahmetovic, M. et al. (2012) Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.
Invest Ophthalmol Vis Sci. 53 (9): 5231-41.
Niewoehner, J. et al. (2014) Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.
Neuron. 81: 49-60.
Sands, S.A. et al. (2015) The habenula and iron metabolism in cerebral mouse models of multiple sclerosis.
Neurosci Lett. 606: 204-8.
View The Latest Product References
Baumann, B. et al. (2017) Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation.
Invest Ophthalmol Vis Sci. 58 (10): 4223-34.
Nelvagal, H.R. et al. (2020) Comparative proteomic profiling reveals mechanisms for early spinal cord vulnerability in CLN1 disease.
Sci Rep. 10 (1): 15157.
Hargreaves, A. et al. (2021) Tumors modulate fenestrated vascular beds and host endocrine status.
J Appl Toxicol. May 11 [Epub ahead of print].
Zhang, K.R. et al. (2022) Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis.
Exp Eye Res. : Mar 07: 109028 [Epub ahead of print].
Hargreaves, A. et al. (2022) Tumours modulate the systemic vascular response to anti-angiogenic therapy.
J Appl Toxicol. Feb 13 [Epub ahead of print].
Lesley, J. et al. (1984) Expression of transferrin receptor on murine hematopoietic progenitors.
Cell Immunol. 83 (1): 14-25.
Trowbridge, I.S. et al. (1982) Murine cell surface transferrin receptor: studies with an anti-receptor monoclonal antibody.
J Cell Physiol. 112 (3): 403-10.
- Transferrin Receptor
- Entrez Gene
- GO Terms
- GO:0005886 plasma membrane
- GO:0008233 peptidase activity
- GO:0005381 iron ion transmembrane transporter activity
- GO:0016021 integral to membrane
- GO:0004998 transferrin receptor activity
- GO:0005768 endosome
- GO:0006508 proteolysis
- GO:0006879 cellular iron ion homeostasis
- GO:0006897 endocytosis
- View More GO Terms
- GO:0042470 melanosome
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular vesicular exosome
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"View all Anti-Mouse Products
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