CD48 antibody | OX-78
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F ResetRat anti Mouse CD48:RPE
- Product Type
- Monoclonal Antibody
- Clone
- OX-78
- Isotype
- IgG2a
- Specificity
- CD48
Antibody Quality and Performance Guarantee
| Rat anti Mouse CD48 antibody, clone OX-78 recognizes murine CD48 antigen, also known as BCM1 surface antigen, BLAST-1, HM48-1, MRC OX-45 surface antigen, SLAM family member 2. CD48 is a 195 amino acid GPI anchored membrane glycoprotein with an additional 22 amino acid signal peptide and a 23 amino acid propeptide region cleaved in the mature form. Rat anti Mouse CD48 antibody, clone OX-78 labels mouse thymocytes, B and T cells and macrophages. CD48 is a ligand for the mouse CD2 cell surface antigen. |
- Target Species
- Mouse
- Product Form
- Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
- Reconstitution
- Reconstitute with 1 ml distilled water
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide 1% Bovine Serum Albumin 5% Sucrose - Immunogen
- Recombinant soluble mouse CD48.
- Fusion Partners
- Spleen cells from immunized AO Rats were fused with cells from the Rat Y3 myeloma cell line.
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) RPE 488nm laser 496 578 - Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Prior to reconstitution store at +4oC. Following reconstitution store at +4oC.
DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Neat | 1/5 |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
How to Use the Spectraviewer
Watch the Tool Tutorial Video ▸- Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
- Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
- Select the lasers and filters you wish to include
- Select combined or multi-laser view to visualize the spectra
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Rat IgG2a Negative Control:RPE | MCA1212PE | F | 100 Tests |
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| Description | Rat IgG2a Negative Control:RPE | ||||||
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse Seroblock FcR | BUF041A | F | 0.1 mg |
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| Description | Mouse Seroblock FcR | ||||||
| Mouse Seroblock FcR | BUF041B | F | 0.5 mg |
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| Description | Mouse Seroblock FcR | ||||||
References for CD48 antibody
-
Kato, K. et al. (1992) CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.
J Exp Med. 176 (5): 1241-9. -
Lapaque, N. et al. (2006) Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts.
Cell Microbiol. 8 (2): 197-206. -
Kashiwakura, Y. et al. (2013) CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim.
Immunology. 139 (1): 48-60. -
Wild, M.K. et al. (1999) Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex.
J Exp Med. 190: 31-41. -
Grassinger, J. et al. (2010) Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential.
Blood. 116 (17): 3185-96. -
Oh, J. et al. (2018) MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells.
J Cell Biol. 217 (4): 1395-410.
- Synonyms
- BLAST-1
- RRID
- AB_321441
- UniProt
- P18181
- Entrez Gene
- Cd48
- GO Terms
- GO:0005515 protein binding
- GO:0007165 signal transduction
- GO:0009897 external side of plasma membrane
- GO:0042110 T cell activation
- GO:0043499 eukaryotic cell surface binding
- GO:0051789 response to protein stimulus
MCA925PE
151258
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