CD26 antibody | H207-1082
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F ResetRat anti Mouse CD26
- Product Type
- Monoclonal Antibody
- Clone
- H207-1082
- Isotype
- IgG2a
- Specificity
- CD26
Antibody Quality and 
Unrivaled 
| Rat anti Mouse CD26 antibody, clone H207-1082 recognizes mouse CD26, which is also known as thymocyte-activating molecule (THAM). Murine CD26 is a type II integral membrane dipeptidyl-peptidase that is expressed at the cell surface as a heterodimer, of approximately 220 kDa, and has a soluble form in the plasma. The CD26 molecule is a multifunctional glycoprotein that has ectopeptidase activity and is also reported to be involved in cell adhesion, signal transduction in T lymphocytes and HIV infection. CD26 is differentially expressed on developing thymocytes and is upregulated on activated T-cells but is not expressed on resting and thioglycollate stimulated macrophages. Expression of CD26 has also been reported on cells from a variety of non-haematopoietic tissues including liver, intestine and kidney. |
- Target Species
- Mouse
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide - Carrier Free
- Yes
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Flow Cytometry | |
1/50 Pack Size: 0.25 mg, 25 µg 1/25 Pack Size: 0.1 mg |
1/100 |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Rat IgG2a Negative Control | MCA1212 | E F | 1 ml |
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Log in | ||
| List Price | Your Price | ||||||
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| Description | Rat IgG2a Negative Control | ||||||
References for CD26 antibody
-
David, F. et al. (1993) Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases.
J Biol Chem. 268:17247-52. -
Marguet, D. et al. (2000) Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.
Proc Natl Acad Sci U S A. 97:6874-9.
Further Reading
-
Vivier, I. et al. (1991) Evidence that thymocyte-activating molecule is mouse CD26 (dipeptidyl peptidase IV).
J Immunol. 147 (2): 447-54.
- Synonyms
- THAM
- RRID
- AB_566676
- UniProt
- P28843
- Entrez Gene
- Dpp4
- GO Terms
- GO:0002020 protease binding
- GO:0004252 serine-type endopeptidase activity
- GO:0004177 aminopeptidase activity
- GO:0008239 dipeptidyl-peptidase activity
- GO:0005102 receptor binding
- GO:0007155 cell adhesion
- GO:0016021 integral to membrane
- GO:0005576 extracellular region
- GO:0004872 receptor activity
- View More GO Terms
- GO:0030139 endocytic vesicle
- GO:0006508 proteolysis
- GO:0008284 positive regulation of cell proliferation
- GO:0009986 cell surface
- GO:0010716 negative regulation of extracellular matrix disassembly
- GO:0016324 apical plasma membrane
- GO:0031258 lamellipodium membrane
- GO:0031295 T cell costimulation
- GO:0042803 protein homodimerization activity
- GO:0043542 endothelial cell migration
- GO:0045121 membrane raft
- GO:0046581 intercellular canaliculus
- GO:0071438 invadopodium membrane
View more products with CD26 specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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