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CD11b antibody | 5C6

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SDS Safety Datasheet SDS
C F IF IP 25 µg loader
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SDS Safety Datasheet SDS
C F IF IP 0.25 mg loader
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SDS Safety Datasheet SDS
C F IF IP 1 mg loader
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Rat anti Mouse CD11b antibody, clone 5C6 recognizes CD11b, also known as the integrin alpha M chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles.

Rat anti Mouse CD11b antibody, clone 5C6 immunoprecipitates a heterodimer of ~165 and ~95 kDa. This clone also exhibits various functional properties, reportedly inhibiting adhesion in vitro and inflammatory recruitment in vivo. Rat anti Mouse CD11b antibody, clone 5C6 also inhibits delayed hypersensitivity, potentiates bacterial infections and inhibits type 1 diabetes.
CiteAb logo - trusted, tested, published

Our CD11b (5C6) Antibody has been referenced in >161 publications*

*Based on June 2020 data from CiteAb's antibody search engine.

Target Species
Species Cross-Reactivity
Target SpeciesCross Reactivity
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide
Carrier Free
Thioglycollate-elicited peritoneal macrophages (TPM)
Approx. Protein Concentrations
IgG concentration 1 mg/ml
Fusion Partners
Spleen cells from AO rats were fused with cells of the Y3 rat myeloma cell line
For research purposes only
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/100
Immunohistology - Frozen
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul
Histology Positive Control Tissue

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References for CD11b antibody

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  9. View The Latest Product References
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    J Neuroinflammation. 17 (1): 238.
  101. Thygesen, C. et al. (2018) Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease.
    Front Cell Neurosci. 12: 397.
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    J Neuroinflammation. 16 (1): 284.
  103. Thei, L. et al. (2018) Extracellular signal-regulated kinase 2 has duality in function between neuronal and astrocyte expression following neonatal hypoxic-ischaemic cerebral injury.
    J Physiol. 596 (23): 6043-62.
  104. Ryan, F. et al. (2018) Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia.
    Front Neurosci. 12: 988.
  105. Rizzi, C. et al. (2018) NGF steers microglia toward a neuroprotective phenotype.
    Glia. 66 (7): 1395-416.
  106. Haight, E.S. et al. (2020) Of mice, microglia, and (wo)men: a case series and mechanistic investigation of hydroxychloroquine for complex regional pain syndrome.
    Pain Rep. 5 (5): e841.
  107. Berve, K. et al. (2020) Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice.
    J Neuroinflammation. 17 (1): 323.
  108. Su, N. et al. (2023) Sub-Retinal Injection of Human Lipofuscin in the Mouse - A Model of "Dry" Age-Related Macular Degeneration?
    Aging Dis. 14 (1): 184-203.
  109. Geladaris, A. et al. (2024) BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair.
    Acta Neuropathol. 147 (1): 75.
  110. Venezia, S. et al. (2021) Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease.
    Parkinsonism Relat Disord. 91: 59-65.
  111. Klawonn, A.M. et al. (2021) Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons.
    Immunity. 54 (2): 225-234.e6.
  112. Wang, F. et al. (2021) Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain.
    Front Cell Neurosci. 15: 768059.

Blocking Assay


Immunohistology - Frozen

Integrin Alpha M Chain
Entrez Gene
GO Terms
GO:0001846 opsonin binding
GO:0004872 receptor activity
GO:0008305 integrin complex
GO:0005634 nucleus
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008201 heparin binding
GO:0009897 external side of plasma membrane
GO:0030593 neutrophil chemotaxis
GO:0043395 heparan sulfate proteoglycan binding
GO:0045123 cellular extravasation
GO:0050798 activated T cell proliferation


151040 166063 1804


154201 163792 1709


152972 166868

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