CD106 antibody | MVCAM A (429)
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|Rat anti Mouse CD106 antibody, clone MVCAM A (429) recognizes murine vascular adhesion molecule 1 (VCAM-1), a cell surface glycoprotein that is also known as CD106. CD106 is expressed predominantly on endothelial cells and expression is up-regulated during inflammation. The ligand for CD106 is the alpha 4 subunit (CD49d) of the integrin VLA-4 (CD49d/CD29).
Rat anti Mouse CD106 antibody, clone MVCAM A (429) is reported to partially block VCAM-1 mediated functions (Kinashi and Springer 1994).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- Stromal cell line PA6.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised Lewis rats were fused with cells of the mouse P3X63Ag8.653 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
References for CD106 antibody
Kinashi, T. and Springer, T.A. (1994) Adhesion molecules in hematopoietic cells.
Blood Cells. 20:25-44.
Lau,. H.Y. and Bhatia, M. (2007) Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice.
Am J Physiol Gastrointest Liver Physiol. 292: G1283-92.
Woo, J.M. et al. (2010) Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.
Arthritis Res Ther. 12(3):R93.
Hall, L.J. et al. (2010) Probing local innate immune responses after mucosal immunisation.
J Immune Based Ther Vaccines. 8: 5.
Winnik S et al. (2011) Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation.
Eur Heart J. 32 (20): 2573-84.
Hamada, T. et al. (2009) Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury.
Am J Pathol. 174: 2265-77.
Hamada, T. et al. (2008) Metalloproteinase-9 deficiency protects against hepatic ischemia/reperfusion injury.
Hepatology. 47: 186-98.
Baumer, Y. et al. (2011) Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells.
Exp Biol Med (Maywood). 236: 692-700.
View The Latest Product References
Li, M. et al. (2014) The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma.
J Immunother Cancer. 2: 21.
Kumpers, P. et al. (2011) The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.
Crit Care. 15 (5): R261.
Püntener, U. et al. (2012) Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia.
J Neuroinflammation. 9: 146.
David, S. et al. (2011) Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis.
Cytokine. 55 (2): 251-9.
Kuriyama, N. et al. (2011) Tenascin-C: a novel mediator of hepatic ischemia and reperfusion injury.
Hepatology. 54 (6): 2125-36.
Braach, N. et al. (2014) RAGE controls activation and anti-inflammatory signalling of protein C.
PLoS One. 9 (2): e89422.
El Amki, M. et al. (2018) Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice.
Mol Neurobiol. 55 (12): 9156-68.
Basic, M. et al. (2020) Lymph Node Stromal Cells From Different Draining Areas Distinctly Regulate the Development of Chronic Intestinal Inflammation.
Front Immunol. 11: 549473.
- Entrez Gene
- GO Terms
- GO:0007157 heterophilic cell-cell adhesion
- GO:0016021 integral to membrane
- GO:0007507 heart development
- GO:0031225 anchored to membrane
- GO:0044419 interspecies interaction between organisms
- GO:0060669 embryonic placenta morphogenesis
- GO:0060710 chorio-allantoic fusion
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