VEGF antibody | Bevacizumab

Human anti VEGF (Bevacizumab Biosimilar)

Product Type
Monoclonal Antibody
Clone
Bevacizumab
Isotype
IgG1
Specificity
VEGF

Product Code Applications Pack Size List Price Your Price Qty
MCA6089
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.2 mg loader
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loader
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Human Anti-VEGF antibody is a research grade biosimilar of the monoclonal antibody drug bevacizumab. This product is supplied in a research grade format, i.e. in PBS buffer with preservative, it is not manufactured or formulated in the same way as the therapeutic reference product. A preservative free version is available on request.

This product is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic bevacizumab antibody clone.

This antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-bevacizumab antibodies, for example HCA182 and HCA185. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-bevacizumab antibody in IgG1 format as a reference standard, for example HCA184 or HCA185.

Bevacizumab, also known as Avastin, is a humanized monoclonal antibody (IgG1 kappa) that inhibits angiogenesis by binding to VEGF-A. VEGF-A stimulates new blood vessel formation in certain diseases, especially in cancer. Avastin is used to treat various cancers, including colorectal, lung, breast, glioblastoma, kidney and ovarian.

This product is NOT FOR THERAPEUTIC USE.

View a summary of supporting anti-bevacizumab antibody products.

Target Species
Human
Product Form
Human IgG1 (kappa) antibody - liquid
Preparation
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Proclin 300
Immunogen
Human VEGF
Purity
>98% by SDS PAGE
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Description Product Code Applications Pack Size List Price Your Price Quantity
Hispec Assay Diluent BUF049A E IY 50 ml
List Price Your Price
Description Hispec Assay Diluent
Human anti Bevacizumab HCA182 E 0.1 mg loader
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loader
Description Human anti Bevacizumab
Human anti Bevacizumab HCA184 E 0.1 mg loader
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Description Human anti Bevacizumab
Human anti Bevacizumab:HRP HCA184P E 0.1 mg loader
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Description Human anti Bevacizumab:HRP
Human anti Bevacizumab HCA185 E 0.1 mg loader
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loader
Description Human anti Bevacizumab
LYNX Rapid HRP Antibody Conjugation Kit LNK001P CJ 1 Conjugation For 400µg Antibody
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Description LYNX Rapid HRP Antibody Conjugation Kit

Licensed Use
For in vitro research purposes only. Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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