Calcitonin Receptor antibody
Rabbit anti Rat Calcitonin Receptor
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Calcitonin Receptor
Antibody Quality and Performance Guarantee
| Rabbit anti rat calcitonin receptor antibody recognizes rat calcitonin receptor, also known as CT-R or C1A/C1B. Calcitonin receptor is a seven-transmembrane domain G protein-coupled receptor that binds the protein hormone calcitonin. It is expressed in kidneys, central and peripheral nervous system, skeletal muscle stem cells and osteocytes. Investigations on calcitonin receptor’s function have mainly focused on its role in regulating calcium homeostasis and osteoclast-mediated bone resorption. However, a growing body of evidence suggests that calcitonin receptor could also be involved in foetal morphogenesis and cancer development. Rabbit anti rat calcitonin receptor antibody binds to an intracellular epitope of the calcitonin receptor that is shared by both C1a and C1b rat calcitonin receptor isoforms. It has been shown to cross-react with mouse calcitonin receptor. |
- Target Species
- Rat
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Human Weak - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - lyophilized
- Reconstitution
- Reconstitute with 100ul distilled water
- Antiserum Preparation
- Antisera to calcitonin receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein A.
- Buffer Solution
- 10 mM Sodium Phosphate
- Preservative Stabilisers
- 0.01% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide derived from a C-terminal sequence of rat calcitonin receptor.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml after reconstitution
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Prior to reconstitution store at +4°C.
After reconstitution store at -20°C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
After reconstitution store at -20°C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/20,000 | |
| Immunocytochemistry | |
1/1,000 | |
| Immunohistology - Frozen | |
1/1,000 | 1/5,000 |
| Western Blotting | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Kidney, cultured osteoclasts
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P32214
- Entrez Gene
- Calcr
- GO Terms
- GO:0005886 plasma membrane
- GO:0016021 integral to membrane
- GO:0004948 calcitonin receptor activity
- GO:0030424 axon
- GO:0032841 calcitonin binding
- GO:0043025 neuronal cell body
View more products with CALCITONIN RECEPTOR specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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