CCL11 antibody
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Rabbit anti Mouse CCL11:Preservative Free
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CCL11
Antibody Quality and Performance Guarantee
| Rabbit anti Mouse CCL11 antibody, recognizes C-C motif chemokine 11 (CCL11), also known as eotaxin, eosinophil chemotactic protein and small inducible cytokine A11. CCL11 is produced by a range of cell types including epithelial cells, fibroblasts, smooth muscle cells, astrocytes, chondrocytes and tissue resident macrophages. Additionally, in the central nervous system, it is expressed by choroid plexus epithelial cells, pericytes, and microglia under inflammatory conditions (Teixeira et al. 2018). CCL11 acts as a chemoattractant for eosinophil recruitment to inflammatory sites, including during asthma attacks (Wen & Rothenberg 2016). Upon binding of CCL11 to its receptor CCR3, a series of signaling events are triggered which can result in calcium mobilization, CD11b upregulation, MAPK activation and actin polymerization. It can also result in a rapid change of shape associated with chemotaxis and granule release (Conroy & Williams 2001). |
- Target Species
- Mouse
- Product Form
- Purified IgG - lyophilized
- Reconstitution
- Reconstitute with 0.1 ml distilled water
- Antiserum Preparation
- Produced from sera of rabbits immunized with recombinant mouse CCL11 and purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant mouse CCL11
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml after reconstitution
- Endotoxin Level
- < 0.1 ng/μg of protein (< 1 EU/μg)
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
0.5 ug/ml | 2.0 ug/ml |
| Western Blotting | |
0.1 ug/ml | 0.2 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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|---|---|---|---|---|---|---|---|
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P48298
- Entrez Gene
- Ccl11
- GO Terms
- GO:0005615 extracellular space
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0008009 chemokine activity
- GO:0045766 positive regulation of angiogenesis
- GO:0060444 branching involved in mammary gland duct morphogenesis
- GO:0060763 mammary duct terminal end bud growth
AHP2811Z
156485
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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