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ACE2 antibody

Rabbit anti Human ACE2 (N-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
ACE2
Region
(N-TERMINAL)

Product Code Applications Pack Size List Price Your Price Qty
AHP888
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P * WB 0.1 mg loader
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loader

Rabbit anti Human ACE2 antibody recognizes human Angiotensin-converting enzyme 2, also known as ACE2, ACE-related carboxypeptidase or Metalloprotease MPROT15. ACE2 is a 788 amino acid ~100 kDa carboxypeptidase expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system.

ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation.

ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein (Turner et al. 2004).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human ACE2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
Synthetic peptide corresponding to a sequence within the amino terminus of human ACE2.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1
Western Blotting
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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Synonyms
Angiotensin I Converting Enzyme 2
RRID
AB_566362
UniProt
Q9BYF1
Entrez Gene
ACE2
GO Terms
GO:0005886 plasma membrane
GO:0001618 viral receptor activity
GO:0001817 regulation of cytokine production
GO:0001948 glycoprotein binding
GO:0002005 angiotensin catabolic process in blood
GO:0003051 angiotensin-mediated drinking behavior
GO:0004180 carboxypeptidase activity
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0016021 integral to membrane
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0006800 oxygen and reactive oxygen species metabolic process
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0019229 regulation of vasoconstriction
GO:0032800 receptor biosynthetic process
GO:0042127 regulation of cell proliferation
GO:0042312 regulation of vasodilation
GO:0045121 membrane raft
GO:0046813 virion attachment, binding of host cell surface receptor
GO:0050727 regulation of inflammatory response

AHP888

155567 156828 160031

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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