ACE2 antibody
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WB ResetRabbit anti Human ACE2 (N-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- ACE2
- Region
- (N-TERMINAL)
Antibody Quality and Performance Guarantee
| Rabbit anti Human ACE2 antibody recognizes human Angiotensin-converting enzyme 2, also known as ACE2, ACE-related carboxypeptidase or Metalloprotease MPROT15. ACE2 is a 788 amino acid ~100 kDa carboxypeptidase expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system. ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation. ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein (Turner et al. 2004). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human ACE2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide - Immunogen
- Synthetic peptide corresponding to a sequence within the amino terminus of human ACE2.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin 1 |  |
||
| Western Blotting | |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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- Synonyms
- Angiotensin I Converting Enzyme 2
- RRID
- AB_566362
- UniProt
- Q9BYF1
- Entrez Gene
- ACE2
- GO Terms
- GO:0005886 plasma membrane
- GO:0001618 viral receptor activity
- GO:0001817 regulation of cytokine production
- GO:0001948 glycoprotein binding
- GO:0002005 angiotensin catabolic process in blood
- GO:0003051 angiotensin-mediated drinking behavior
- GO:0004180 carboxypeptidase activity
- GO:0008237 metallopeptidase activity
- GO:0008241 peptidyl-dipeptidase activity
- View More GO Terms
- GO:0016021 integral to membrane
- GO:0005615 extracellular space
- GO:0006508 proteolysis
- GO:0006800 oxygen and reactive oxygen species metabolic process
- GO:0008270 zinc ion binding
- GO:0009986 cell surface
- GO:0019229 regulation of vasoconstriction
- GO:0032800 receptor biosynthetic process
- GO:0042127 regulation of cell proliferation
- GO:0042312 regulation of vasodilation
- GO:0045121 membrane raft
- GO:0046813 virion attachment, binding of host cell surface receptor
- GO:0050727 regulation of inflammatory response
AHP888
155567
156828
160031
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