Neuroscience: Development and Repair Antibodies
Overview
Development of the nervous system occurs via cellular and molecular mechanisms arising during embryogenesis. Neurogenesis encompasses the differentiation of neural stem cells (NSC) first into neurons, and later into axonal outgrowth via growth cones that respond to guidance cues, such as Ephrins, Semaphorins, Plexins, Neuropilins, and Netrins.
Antibodies for Studying Axonal Growth
The extraordinary level of accuracy during axonal outgrowth is of huge interest to researchers. Our key growth cone marker (MCA1712, clone 2G13) is ideal for studying axonal growth. The target recognized by this antibody, 2G13P, is localized to growth cones, particularly filopodia and lamellipodies in developing rat CNS and embryonic neurons in culture.
Studies suggest that the protein detected interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility. Additional key axonal growth antibodies are also available.
Neuroscience Development and Repair Antibodies
| Description | Target | Format | Clone | Applications | Citations | Code |
|---|
Further Reading
-
Stettler O et al. (1999). Monoclonal antibody 2G13, a new axonal growth cone marker.
J. Neurocytol. 28, 1035 - 1044.
Be the First to Receive Updates on Products and Resources
You'll receive regular communications featuring free lab resources such as application guides, posters, mini-reviews, protocols, practical tips, webinar invitations, special offers, and updates on new research tools and products.
You'll also get our specialist newsletters—including Fab Fragments, Flow. Sorted., and RiVETing—along with news on the latest antibody innovations, such as TrailBlazer™ Antibodies and StarBright™ Dyes.
During sign-up, you can choose your areas of interest so you only receive content relevant to your research, and you can unsubscribe at any time.
