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Secukinumab antibody | AbD37091ia

Human anti Secukinumab

Product Type
Monoclonal Antibody

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Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.1 mg loader
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Human Anti-Secukinumab Antibody, clone AbD37091ia is a paratope specific, inhibitory anti-idiotypic antibody that specifically recognizes the human monoclonal antibody secukinumab. It does not recognize free human interleukin 17A (IL-17A) nor secukinumab in complex with human IL-17A. The antibody can be used to measure secukinumab or its biosimilars in patient samples.

A pair of anti-secukinumab antibodies can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. Either this antibody, or clone AbD37054ia (HCA371), is recommended as the detection antibody, paired with an anti-secukinumab antibody in monovalent Fab format, clone AbD37052 (HCA370), as the capture antibody.

Clone AbD37091ia is a fully human recombinant monoclonal antibody with IgG1 isotype and can be used as a surrogate positive control or reference standard in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 5 nM, and is one of three antibodies with different affinities offered for ADA assays.

Secukinumab (Cosentyx) is a human IgG1/kappa antibody generated using transgenic mouse technology. It has been approved for the treatment of plaque psoriasis, ankylosing spondylitis, psoriatic arthritis and non-radiographic axial spondyloarthritis. Secukinumab inhibits IL-17A produced mainly by inflammatory T helper 17 cells (Lubrano and Perrotta 2016).

View a summary of all anti- secukinumab antibodies

Product Form
Human IgG1 antibody (lambda light chain) selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
The intrinsic affinity of the monovalent form of Human anti Secukinumab antibody, clone AbD37091ia is KD = 5 nM as measured by real time, label free molecular interaction analysis on immobilized Secukinumab.
Approx. Protein Concentrations
Antibody concentration 0.5 mg/ml
For research purposes only
12 months from date of despatch
This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See for details.
Cosentyx is a trademark of Novartis.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Technical Advice
Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
Human anti Secukinumab antibody, clone AbD37091ia is suitable for use as a detection antibody for Secukinumab in a bridging ELISA together with HCA370 as the capture reagent. It can also be used as a surrogate positive control or calibrator in an anti-drug antibody assay.
Protocol: PK bridging ELISA.
Protocol: ADA bridging ELISA.

Description Product Code Applications Pack Size List Price Your Price Quantity
Hispec Assay Diluent BUF049A E IY 50 ml
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Description Hispec Assay Diluent
Human anti Secukinumab HCA370 E 0.1 mg
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Description Human anti Secukinumab
Human anti Secukinumab HCA371 E 0.1 mg
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Description Human anti Secukinumab
Human anti Secukinumab HCA373 E 0.1 mg
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Description Human anti Secukinumab
Human anti Secukinumab (Drug/Target Complex) HCA375 E 0.1 mg
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Description Human anti Secukinumab (Drug/Target Complex)
LYNX Rapid HRP Antibody Conjugation Kit LNK002P CJ 3 Conjugations For 400µg Antibody
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Description LYNX Rapid HRP Antibody Conjugation Kit

Further Reading

  1. Lubrano, E. & Perrotta, F.M. (2016) Secukinumab for ankylosing spondylitis and psoriatic arthritis.
    Ther Clin Risk Manag. 12: 1587-1592.

Licensed Use
For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.


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