CD206 antibody | MR5D3
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used for the evaluation of mannose expression by primary microglia from wild type and IL-1 knockout mice by western blotting of isolated microglial lysates.
Image caption:
Western blot analysis to identify the type of activation of adult primary microglial cells from wild-type and IL-1 KO mice stimulated by vehicle, IFNγ or IL-4 with or without IL-1β. (A) Representative western blotting data of primary MG produced from wild-type (wild) and IL-1 KO mice exposed for 24 hours to vehicle, IFNγ or IL-4 with or without IL-1β. Each lane expected to CD206 blotting applied 8 μg of reduced samples. Non-reduced samples (5 μg) were applied to detect CD206. Densitometric analysis of STAT1 (B), COX2 (C), iNOS (D), Ym1 (E), Arg-1 (F) and CD206 (G) (n = 3 each group). (B) STAT1 level is increased by exposure of cells to IFNγ, but not to IL-4. The level is not influenced by co-treatment of cells with IL-1β. (C) The COX2 level is increased by exposure of cells to IL-1β but not to IFNγ or IL-4 alone. Co-treatment with IL-1β and IL-4 tends to increase the COX2 level synergistically. (D) While the iNOS level is not increased significantly by exposure of cells to IFNγ or IL-4, the level increased synergistically in response to co-treatment with IFNγ and IL-1β. (D) The level of Ym1 is increased by exposure of cells to IL-4 and further increased by co-treatment with IL-1β. (E) The Arg-1 level is also increased by exposure of cells to IL-4 and further increased by co-treatment with IL-1β. (G) The CD206 level is increased slightly by exposure of cells to IL-4, but not with co-treatment with IL-4 and IL-1β. Data are expressed as mean ± SD (n = 3). *: P < 0.05, **: P < 0.01, ***: P < 0.001 compared to the vehicle-treated group without IL-1β for each genotype (One-way ANOVA followed by Dunnett post-hoc test). ANOVA, analysis of variance; arg-1, arginase 1; COX2, cyclooxygenase 2; iNOS, inducible NO synthase.
From: Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, Iwakura Y, Atsumi T, Shioda S.
Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury.
J Neuroinflammation. 2012 Apr 7;9:65.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used for the evaluation of mannose expression by primary microglia from wild type and IL-1 knockout mice by western blotting of isolated microglial lysates.
Image caption:
Western blot analysis to determine type of activation of adult primary microglial cells produced from wild-type and IL-1 KO mice stimulated with IL-4, IL-13 or IL-4/IL-13 with or without IL-1β. (A) Representative western blotting data of primary microglial cells produced from wild-type (wild) and IL-1 KO mice and exposed for 24 hours to IL-4, IL-13 or IL-4 plus IL-13 (IL-4/IL-13) with or without IL-1β. Each lane expected to CD206 blotting were applied 7 μg of reduced samples. Non-reduced samples (5 μg) were applied to detect CD206. Densitometric analysis of COX2 (B), Ym1 (C), Arg-1 (D) and CD206 (E) (n = 3 each group). (B) COX2 levels are increased by exposure of cells to IL-1β and are not influenced by IL-4 or IL-13 alone. The COX2 level was slightly enhanced by IL-1β and IL-4 co-treatment. (C) Ym1 levels are increased by exposure of cells to IL-4 and IL-4/Il-13 and are synergistically increased by co-treatment with IL-1β. However, only a low level of Ym1 is seen upon exposure of cells to IL-13, and is significantly less than that seen in response to exposure of cells to IL-4. (D) Arg-1 shows similar levels in response to exposure to IL-4 and IL-4/IL-13; these are synergistically increased by co-treatment with IL-1β. However, low levels of Arg-1 are seen for exposure of cells to IL-13. (G) CD206 was detected in response to exposure of cells to both IL-4 and IL-4/IL-13 with or without IL-1β; however, CD206 levels in IL-13-exposed samples were lower than those seen with the other treatments. Data are expressed as mean ± SD (n = 3). *: P <0.05, **: P <0.01, ***: P <0.001 compared with the IL-4-treated group without IL-1β for each genotype (one-way ANOVA followed by Dunnett post-hoc test). ANOVA, analysis of variance; arg-1, arginase 1; COX 2, cyclooxygenase 2.
From: Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, Iwakura Y, Atsumi T, Shioda S.
Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury.
J Neuroinflammation. 2012 Apr 7;9:65.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used for the detection of mannose receptor expressing macrophages in hind limbs of control and ischemia induced mice by immunofluorescence.
Image caption:
Increased accumulation of repair-associated macrophages surrounding collaterals in ischemic hind limbs is PAR2-dependent. (A) Stainings of CD206-positive macrophages (green) and SMA-positive vessels (red) in non-ischemic (control) and ischemic (ligated) hind limbs of WT, PAR1-/- and PAR2-/- mice are shown. Nuclei were visualized with DAPI (blue). Arrows indicate single macrophages in the non-ischemic adductor. Quantification of the average number of repair-associated macrophages per vessel is indicated on the right. (B) Correlation between the number of CD206-positive macrophages in the ischemic tissues and the expression of CD11b and (C) CD115 on monocytes. ** p<0.01, *** p<0.001.
From: van den Hengel LG, Hellingman AA, Nossent AY, van Oeveren-Rietdijk AM, de Vries MR, Spek CA, et al. (2013)
Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model.
PLoS ONE 8(4): e61923.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used for the evaluation of alternative macrophage activation in the lungs of fibrotic IFNγ knockout and wild type mice by flow cytometry on isolated cells.
Image caption:
Elevated levels of alternative macrophage activation are observed in lung of fibrotic IFNγR-/- C57Bl/6 mice. 8–12 week old C57Bl/6 IFNγR-/- mice were intranasally infected with 1x105 pfu MHV68 (WT or M1st) and sacrificed at indicated times post infection (n = 3–4 mice/group at each timepoint). Whole lungs were harvested and assessed for macrophage population and phenotype. (A-B) Absolute number of alveolar and interstitial macrophages were quantified and assessed for alternative activation using RELMα and CD206 expression.
From: O'Flaherty BM, Matar CG, Wakeman BS, Garcia A, Wilke CA, Courtney CL, et al. (2015)
CD8+ T Cell Response to Gamma herpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.
PLoS ONE 10(8): e0135719.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235GA) used for the illustration of mannose receptor expressing cells in murine liver by immunofluorescence.
Image caption:
Immunohistochemical analysis of expression of FPR1 in human and mouse liver tissue.
Liver sections were fixed with cold acetone for 10 min, washed in PBS and incubated overnight at 4°C with polyclonal rabbit anti-FPR1 (1:200), followed by Alexa Fluor®-488 goat anti-rabbit (1:1000). Intense FPR1 staining can be observed along the sinusoids in mouse liver (A), while in human liver the staining was more evenly localized to both LSECs and Heps (B). Double staining was performed using polyclonal rabbit anti-FPR1, rat anti-mouse CD206, and goat anti-human CD206, followed by Alexa Fluor®-488 and Alexa Fluor®-594 secondary antibodies, respectively.
From: Øie, C.I. Snapkov, I. Elvevold, K. Sveinbjørnsson, B. Smedsrød, B. (2016)
FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides.
PLoS ONE 11(8): e0160602.
doi:10.1371/journal.pone.0160602
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used for the evaluation of CD206 expression on BV-2 microglial cells following cytokine treatment in vitro by immunofluorescence.
Image caption:
cPLA2α is not involved in the induction of the BV-2 cells towards M2 phenotype induced by IL-4 + IL-10. A representative double-immunofluorescence staining of cPLA2α (green) and CD206 (red) in the unstimulated or stimulated BV-2 cells with IL-4 (20 ng/ml) + IL-10 (20 ng/ml) for 24 h in the absence or presence of AS or SE. DAPI staining shows cell nuclei. Scale bars = 100μm. a The intensity of CD206 or cPLA2α were quantitated and expressed in the bar graph as arbitrary units. The bar graphs are the mean ± SE from three independent experiments. b A representative immunoblot analysis of arginase 1 protein expression in the cells treated as in a. The intensity of each Arg1 band after quantification by densitometry was divided by the intensity of each calreticulin band and expressed as arbitrary units. The bar graphs are the mean ± SE from three independent experiments (***p<0.0001, n.s. not significant).
From: Malada-Edelstein, Y.F. Hadad, N. Levy, R.
Regulatory role of cytosolic phospholipase A(2) alpha in the induction of CD40 in microglia.
J Neuroinflammation. 2017 Feb 10;14(1):33.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used to label MMR expressing macrophages in mouse brain by immunofluorescence.
Image caption:
5XFAD/TNFΔARE/+ mice display increased CD206-positive meningeal and perivascular macrophages (arrows). (A – C) Double immunofluorescence for CD206/Iba1 (A) and CD206/α-SMA (B, C) in sagittal brain sections of 4-month-old 5XFAD and 5XFAD/TNFΔARE/+ mice. Representative pictures of the hippocampus, cortex and cortical vessels are shown for each group. Arrowheads indicate meningeal macrophages (A) and perivascular CD206-positive macrophages in the cortex (B) and the hippocampus (C). Microglia is stained red (A) as well as blood vessels (B, C) Scale bars: 25 μm.
From: Kalovyrna N, Apokotou O, Boulekou S, Paouri E, Boutou A, Georgopoulos S.
A 3'UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice.
Sci Rep. 2020 May 26;10(1):8670.
doi: 10.1038/s41598-020-65378-2.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used to label MMR expressing macrophages in mouse brain by western blotting.
Image caption:5XFAD/TNFΔARE/+ mice display increased CD206-positive meningeal and perivascular macrophages (arrows). (D-G) Western blot analysis of CD206 brain protein levels in 4-month-old 5XFAD/TNFΔARE/+ – 5XFAD (D) and TNFΔARE/+ – C57BL/6 mice (F) revealed an increase in 5XFAD/TNFΔARE/+ (E) and TNFΔARE/+ mice (G) compared with the 5XFAD and C57BL/6 control groups. Quantitation was performed with densitometric analysis using ImageJ software. Data are mean ± SEM; n = 3 mice per group; experiment repeated 3 times. For statistical analyses, two-tailed unpaired t test was used. **p = 0.0099, *p = 0,0403.
From: Kalovyrna N, Apokotou O, Boulekou S, Paouri E, Boutou A, Georgopoulos S.
A 3'UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice.
Sci Rep. 2020 May 26;10(1):8670.
doi: 10.1038/s41598-020-65378-2.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used to identify M2 macrophages in murine adipose tissue by immunofluorescence.
Image caption:
Expression of M2 markers CD206 and CD301 by ATMs of induced CLS and interstitial macrophages. M2 ATMs outside of CLS are highlighted by arrows. Scale bars = 50 μm.
From: Lindhorst A, Raulien N, Wieghofer P, Eilers J, Rossi FMV, Bechmann I, Gericke M.
Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages.
Cell Death Dis. 2021 Jun 5;12(6):579.
doi: 10.1038/s41419-021-03872-9.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
FITC conjugated Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235F) used to evaluate mannose receptor expression levels on mouse peritoneal exudate cells by flow cytometry.
Image caption:
The level of receptor expression on CD11b+ cells in the peritoneal cavity in mice infected with T. spiralis and/or injected with chitosan 5 days after infection (DAI) (A) and 30 DAI (B); representative dot plots 5 DAI (C): grey area—unlabeled cells, black line—T. spiralis infected mice, grey line—treated with chitosan and infected with the nematode. (*) p <0.05, chitosan vs. non treated; (#) p <0.05, infected vs. control.
From: Brodaczewska K, Wolaniuk N, Lewandowska K, Donskow-Łysoniewska K, Doligalska M.
Biodegradable Chitosan Decreases the Immune Response to Trichinella spiralis in Mice.
Molecules. 2017 Nov 18;22(11):2008.
doi: 10.3390/molecules22112008.
This image is from an open access article distributed under terms of a Creative Commons Attribution License..
Rat anti mouse CD206 antibody, clone MR5D3 (MCA2235) used to label M2 macrophages by immunofluorescence.
Image caption:
Reduction of intratumor M2 macrophages by EIPA/Cis and ESO treatments. (A) Double immunofluorescence analysis with anti‐CD206 (green) and anti‐NHE‐1 (red, a and c) or anti‐v‐ATPase (red, b and d) of 4T1 tumors from untreated (a and b) or EIPA/Cis‐treated (c and d) mice. (B) Double immunofluorescence analysis with anti‐CD206 (green) and anti‐v‐ATPase (red, a and c) or anti‐NHE‐1 (red, b and d) of TS/A tumors from untreated (a and b) or ESO‐treated (c and d) mice. Scale bar, 30 μm
From: Balza E, Carlone S, Carta S, Piccioli P, Cossu V, Marini C, Sambuceti G, Rubartelli A, Castellani P.
Therapeutic efficacy of proton transport inhibitors alone or in combination with cisplatin in triple negative and hormone sensitive breast cancer models.
Cancer Med. 2022 Jan;11(1):183-193.
doi: 10.1002/cam4.4371.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235GA) used to identify M2-like macrophages in murine tumors by immunofluorescence.
Image caption:
Reduction of M2-like TAMs by melittin–dKLA in a mouse model of melanoma. Single cells were harvested from tumor tissues. (D) Expression of CD206 in tumor tissues was determined by immunofluorescence staining assay. Confocal images of a tumor tissue slice stained for CD206 (red), and nucleus (DAPI; blue). (E) The graph is presented as intensity relative to PBS. All data are presented as means ± SD (n = 5); * p <0.05 versus the PBS group.
From: Han, I.-H.; Jeong, C.; Yang, J.; Park, S.-H.; Hwang, D.-S.; Bae, H.
Therapeutic Effect of Melittin–dKLA Targeting Tumor-Associated Macrophages in Melanoma.
Int J Mol Sci. 2022, 23, 3094.
doi: 10.3390/ijms23063094
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used to label CD206+ macrophages in the murine dorsal root ganglia by immunofluorescence.
Image caption:
Macrophage subtypes in DRG of old WT and GLA KO mice. (A–F) Representative photomicrographs of F4/80+ (A,D), CD80+ (B,E), and CD206+ (C,F) macrophages (arrowheads) in DRG of old WT and old GLA KO mice. (G) Quantification of F4/80+ pan-macrophages per mm2 DRG area in old WT (●, n = 5) and old GLA KO mice (◯, n = 5). (H) Quantification of CD80+ M1 macrophages per mm2 DRG area in old WT (●, n = 5) and old GLA KO mice (◯, n = 5). (I) Quantification of CD206+ M2 macrophages per mm2 DRG area in old WT (●, n = 5) and old GLA KO mice (◯, n = 5). Abbreviations: CD = Cluster of Differentiation; DAPI = 4′,6-diamidino-2-phenylindole; DRG = dorsal root ganglia; GLA KO = alpha-galactosidase A knockout; WT = wildtype. Scale bar: 25 μm. ** p <0.01.
From: Spitzel M, Wagner E, Breyer M, Henniger D, Bayin M, Hofmann L, Mauceri D, Sommer C, Üçeyler N.
Dysregulation of Immune Response Mediators and Pain-Related Ion Channels Is Associated with Pain-like Behavior in the GLA KO Mouse Model of Fabry Disease.
Cells. 2022 May 24;11(11):1730.
doi: 10.3390/cells11111730.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Rat anti Mouse CD206 antibody, clone MR5D3 (MCA2235) used to evaluate CD206 expression on mouse macrophages by flow cytometry.
Image caption:
No effect of orexin A supplementation on adipose tissue inflammation in Ox-/- mice fed HFD.
(B) No effect of ICV-orexin A on the protein levels of M1/M2-macrophage polarization markers (CD11c and CD206) detected by flow cytometry in the eWAT of Ox-/- mice fed HFD. n=5-10/group. *P<0.05 determined by one-way ANOVA with Dunnett’s test. Data are represented as mean ± SEM.
From: Tsuneki H, Maeda T, Takata S, Sugiyama M, Otsuka K, Ishizuka H, Onogi Y, Tokai E, Koshida C, Kon K, Takasaki I, Hamashima T, Sasahara M, Rudich A, Koya D, Sakurai T, Yanagisawa M, Yamanaka A, Wada T, Sasaoka T.
Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity.
Cell Rep. 2022 Oct 18;41(3):111497.
doi: 10.1016/j.celrep.2022.111497.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
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C IF WB F ResetRat anti Mouse CD206
- Product Type
- Monoclonal Antibody
- Clone
- MR5D3
- Isotype
- IgG2a
- Specificity
- CD206
Antibody Quality and Performance Guarantee
| Rat anti Mouse CD206 antibody, clone MR5D3 recognizes the mouse mannose receptor, a ~175 kDa type 1 membrane glycoprotein that is also known as CD206. CD206 is expressed on most tissue macrophages, certain endothelial cells and in vitro derived dendritic cells (Zamze et al. 2002). The mannose receptor, CD206, is composed of a N-terminal cysteine-rich domain, a fibronectin type II domain, eight tandemly arranged C-type lectin domains (CTLD), a transmembrane domain, and a cytoplasmic domain. The terminal cysteine-rich domain binds sulfated sugars, and the CTLD recognizes carbohydrates terminating in mannose, fucose and N-acetylglucosamine, all sugars found on microorganisms and on some endogenous proteins (Su et al. 2005). Rat anti mouse CD206 antibody, clone MR5D3 has been reported to be non-inhibitory for the binding of the mannose receptor to carbohydrate ligands (Zamze et al. 2002). Clone MR5D3 has also been shown to work in western blotting (Martinez-Pomares et al. 2003 and Su et al. 2005). |
Our CD206 (MR5D3) Antibody has been referenced in >107 publications* *Based on June 2020 data from CiteAb's antibody search engine. |
- Target Species
- Mouse
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- Chimaeric CRD4-7-Fc protein
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized Fischer rats were fused with cells of the Y3 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry 1 |  |
1/10 | 1/20 |
| Immunofluorescence | |
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| Immunohistology - Frozen | |
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| Immunoprecipitation | |
- 1 CD206 is expressed weakly at the cell surface. Staining may be increased following membrane permeabilisation. We recommend the use of Leucoperm (Product Code BUF09) for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cell in 100μl
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|---|---|---|---|---|---|---|---|
| Rat IgG2a Negative Control | MCA1212 | E F | 1 ml |
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Source Reference
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Zamze, S. et al. (2002) Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor.
J Biol Chem. 277 (44): 41613-23.
References for CD206 antibody
-
Martinez-Pomares, L. et al. (2003) Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies.
J Leukoc Biol. 73 (5): 604-13. -
Su, Y. et al. (2005) Glycosylation influences the lectin activities of the macrophage mannose receptor.
J Biol Chem. 280: 32811-20. -
Hassan, M.F. et al. (2006) The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani.
Am J Pathol. 169: 943-53. -
Devey, L. et al. (2009) Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism.
Mol Ther. 17: 65-72. -
Vetrone, S.A. et al. (2009) Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta.
J Clin Invest. 119: 1583-94. -
Autenrieth, S.E. & Autenrieth, I.B. (2009) Variable antigen uptake due to different expression of the macrophage mannose receptor by dendritic cells in various inbred mouse strains.
Immunology 127: 523-9. -
Westcott, D.J. et al. (2009) MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity.
J Exp Med. 206: 3143-56. -
Nair, M.G. et al. (2009) Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.
J Exp Med. 206: 937-52.
View The Latest Product References
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Takagi, H. et al. (2009) Cooperation of specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) and complement receptor type 3 (CR3) in the uptake of oligomannose-coated liposomes by macrophages.
Glycobiology 19: 258-66. -
Bacci, M. et al. (2009) Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease.
Am J Pathol. 175: 547-56. -
Hawkes, C.A. et al. (2009) Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy.
Proc Natl Acad Sci USA106: 1261-6. -
deSchoolmeester, M.L. et al. (2009) The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity.
Immunology 126: 246-55. -
Famulski, K.S. et al. (2010) Alternative macrophage activation-associated transcripts in T-cell-mediated rejection of mouse kidney allografts.
Am J Transplant 10 (3): 490-7. -
Hardison, S.E. et al. (2010) Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection.
Am J Pathol. 176: 774-85. -
Lin, J.S. et al. (2010) Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast.
J Leukoc Biol. 88: 95-106. -
Chavele, K.M. et al. (2010) Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.
J Clin Invest. 120: 1469-78. -
Hardison, S.E. et al. (2010) Interleukin-17 Is Not Required for Classical Macrophage Activation in a Pulmonary Mouse Model of Cryptococcus neoformans Infection.
Infect Immun. 78: 5341-51. -
Asano, J. et al. (2010) Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo.
J Immunol. 184: 736-45. -
Dewals, B.G. et al. (2010) IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness.
PLoS Negl Trop Dis. 4 (5): e689. -
Zehner, M. et al. (2011) Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation.
Proc Natl Acad Sci USA 108: 9933-8. -
Geier, H. & Celli, J. (2011) Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis.
Infect Immun. 79 (6): 2204-14. -
Deepe, G.S. Jr. & Buesing, W.R. (2011) Deciphering the Pathways of Death of Histoplasma capsulatum-Infected Macrophages: Implications for the Immunopathogenesis of Early Infection.
J Immunol. 188: 334-44. -
Kondo, Y. et al. (2011) Macrophages counteract demyelination in a mouse model of globoid cell leukodystrophy.
J Neurosci. 31: 3610-24. -
Sindrilaru, A. et al. (2011) An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.
J Clin Invest. 121: 985-97. -
Schneider, D. et al. (2012) Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.
J Immunol. 188 (6): 2894-904. -
Joyce, K.L. et al. (2012) Using eggs from Schistosoma mansoni as an in vivo model of helminth-induced lung inflammation.
J Vis Exp. Jun 5 (64): e3905. -
Fridlender, Z.G. et al. (2013) Using macrophage activation to augment immunotherapy of established tumours.
Br J Cancer. 108 (6): 1288-97. -
Eskilsson, A. et al. (2014) Distribution of microsomal prostaglandin E synthase-1 in the mouse brain.
J Comp Neurol. 522 (14): 3229-44. -
Espagnolle, N. et al. (2014) Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells.
Cancers (Basel). 6 (1): 472-90. -
Sameshima, A. et al. (2015) Teneligliptin improves metabolic abnormalities in a mouse model of postmenopausal obesity.
J Endocrinol. 227 (1): 25-36. -
Manning, C.N. et al. (2015) Adipose-derived mesenchymal stromal cells modulate tendon fibroblast responses to macrophage-induced inflammation in vitro.
Stem Cell Res Ther. 6: 74. -
Verheijden, S. et al. (2015) Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.
Glia. 63 (9): 1606-20. -
O'Flaherty, B.M. et al. (2015) CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.
PLoS One. 10 (8): e0135719. -
Øie, C.I. et al. (2016) FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides.
PLoS One. 11 (8): e0160602. -
Litvack ML et al. (2016) Alveolar-like Stem Cell-derived Myb(-) Macrophages Promote Recovery and Survival in Airway Disease.
Am J Respir Crit Care Med. 193 (11): 1219-29. -
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- Synonyms
- Mannose Receptor C Type 1
- RRID
- AB_324622
- UniProt
- Q61830
- Entrez Gene
- Mrc1
- GO Terms
- GO:0016021 integral to membrane
- GO:0004888 transmembrane receptor activity
- GO:0005537 mannose binding
- GO:0006897 endocytosis
- GO:0009986 cell surface
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