CD105 antibody | MJ7/18
|Rat anti Mouse CD105 antibody, clone MJ7/18 recognizes mouse CD105, also known as Endoglin, a cell surface glycoprotein member of the TGF beta receptor complex. CD105 is a homodimer that forms a heteromeric complex with TGF beta receptors I and/or II. The complex binds TGF beta 1 and 3 efficiently, and TGF beta 2 less efficiently. It may also play a role in the binding of endothelial cells to integrins and cytoskeletal organisation. It is involved in cardiovascular development. CD105 is expressed on endothelial cells in all tissues except bone marrow and in also found in stromal cells within the connective tissue of the intestine, stomach and heart. It may be a useful marker for proliferating endothelium in tumours.|
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Inflamed mouse skin.
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
|Immunohistology - Paraffin|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
References for CD105 antibody
Ge, A.Z. & Butcher, E.C. (1994) Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand.
Gene. 138 (1-2): 201-6.
Hallmann, R. et al. (1995) Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier.
Dev Dyn. 202 (4): 325-32.
Bredow, S. et al. (2000) Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin.
Eur J Cancer. 36 (5): 675-81.
Leguerney, I. et al. (2015) Molecular ultrasound imaging using contrast agents targeting endoglin, vascular endothelial growth factor receptor 2 and integrin.
Ultrasound Med Biol. 41 (1): 197-207.
Crouch, E.E. et al. (2015) Regional and Stage-Specific Effects of Prospectively Purified Vascular Cells on the Adult V-SVZ Neural Stem Cell Lineage.
J Neurosci. 35 (11): 4528-39.
Işık, S. et al. (2016) Intraperitoneal mesenchymal stem cell administration ameliorates allergic rhinitis in the murine model.
Eur Arch Otorhinolaryngol. Jul 5. [Epub ahead of print]
Winkler, S. et al. (2015) Mouse white adipose tissue-derived mesenchymal stem cells gain pericentral and periportal hepatocyte features after differentiation in vitro, which are preserved in vivo after hepatic transplantation.
Acta Physiol (Oxf). 215 (2): 89-104.
- Entrez Gene
- GO Terms
- GO:0001300 chronological cell aging
- GO:0001569 patterning of blood vessels
- GO:0001947 heart looping
- GO:0007155 cell adhesion
- GO:0016021 integral to membrane
- GO:0007179 transforming growth factor beta receptor signaling pathway
- GO:0050431 transforming growth factor beta binding
- GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
- GO:0042803 protein homodimerization activity
- View More GO Terms
- GO:0048745 smooth muscle tissue development
- GO:0048844 artery morphogenesis
- GO:0048845 venous blood vessel morphogenesis
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