Rabbit anti Human PTEN tumor suppressor protein antibody recognizes phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, also known as MMAC1, TEP1. PTEN is a lipid and protein phosphatase that can suppress the PI3K/AKT signaling pathway, which plays roles in regulating cell metabolism, survival, proliferation, apoptosis, growth and migration. In this way, PTEN acts as a tumor suppressor, and loss of PTEN drives many human cancers. Mutations in PIK3CA, PTEN, and/or AKT1 are present in over 40% of uterine, lung, breast, prostate, brain, and head and neck cancers (Chang et al. 2019). PTEN also has important roles in immune signaling pathways, regulates immune cell development, and helps generate antiviral responses (Chen and Guo, 2017). In the nucleus, PTEN has also been found to mediate cellular proliferation and stablize the genome (Morotti et al. 2015).
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of Human PTEN tumor suppressor protein
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
- 12 months from date of despatch
- Entrez Gene
- GO Terms
regulation of cyclin-dependent protein kinase activity
magnesium ion binding
negative regulation of protein phosphorylation
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
induction of apoptosis
central nervous system development
protein tyrosine/serine/threonine phosphatase activity
internal side of plasma membrane
regulation of neuron projection development
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
PDZ domain binding
negative regulation of cell migration
inositol phosphate dephosphorylation
nerve growth factor receptor signaling pathway
T cell receptor signaling pathway
positive regulation of transcription factor activity
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
negative regulation of focal adhesion assembly
negative regulation of protein kinase B signaling cascade
canonical Wnt receptor signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of PTEN Tumor Suppressor Protein antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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