PTEN Tumor Suppressor Protein antibody | RM265
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WB P ResetRabbit anti PTEN Tumor Suppressor Protein
- Product Type
- Monoclonal Antibody
- Clone
- RM265
- Isotype
- IgG
- Specificity
- PTEN Tumor Suppressor Protein
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Antibody Quality and 
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| Rabbit anti Human PTEN tumor suppressor protein antibody recognizes phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, also known as MMAC1, TEP1. PTEN is a lipid and protein phosphatase that can suppress the PI3K/AKT signaling pathway, which plays roles in regulating cell metabolism, survival, proliferation, apoptosis, growth and migration. In this way, PTEN acts as a tumor suppressor, and loss of PTEN drives many human cancers. Mutations in PIK3CA, PTEN, and/or AKT1 are present in over 40% of uterine, lung, breast, prostate, brain, and head and neck cancers (Chang et al. 2019). PTEN also has important roles in immune signaling pathways, regulates immune cell development, and helps generate antiviral responses (Chen and Guo 2017). In the nucleus, PTEN has also been found to mediate cellular proliferation and stablize the genome (Morotti et al. 2015). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the C-terminus of Human PTEN tumor suppressor protein
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/1000 | 1/2000 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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- UniProt
- P60484
- Entrez Gene
- PTEN
- GO Terms
- GO:0000079 regulation of cyclin-dependent protein kinase activity
- GO:0000287 magnesium ion binding
- GO:0001933 negative regulation of protein phosphorylation
- GO:0006915 apoptosis
- GO:0004438 phosphatidylinositol-3-phosphatase activity
- GO:0005829 cytosol
- GO:0004722 protein serine/threonine phosphatase activity
- GO:0004725 protein tyrosine phosphatase activity
- GO:0006470 protein dephosphorylation
- View More GO Terms
- GO:0008289 lipid binding
- GO:0006917 induction of apoptosis
- GO:0007417 central nervous system development
- GO:0008138 protein tyrosine/serine/threonine phosphatase activity
- GO:0008283 cell proliferation
- GO:0009898 internal side of plasma membrane
- GO:0010975 regulation of neuron projection development
- GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
- GO:0016605 PML body
- GO:0050821 protein stabilization
- GO:0019899 enzyme binding
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0030165 PDZ domain binding
- GO:0030336 negative regulation of cell migration
- GO:0046855 inositol phosphate dephosphorylation
- GO:0046856 phosphatidylinositol dephosphorylation
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0050852 T cell receptor signaling pathway
- GO:0051091 positive regulation of transcription factor activity
- GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
- GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
- GO:0051895 negative regulation of focal adhesion assembly
- GO:0051898 negative regulation of protein kinase B signaling cascade
- GO:0060070 canonical Wnt receptor signaling pathway
View more products with PTEN TUMOR SUPPRESSOR PROTEIN specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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