CD195 antibody | HEK/1/85a



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IP IF ResetRat anti Human CD195
- Product Type
- Monoclonal Antibody
- Clone
- HEK/1/85a
- Isotype
- IgG2a
- Specificity
- CD195
Rat anti Human CD195 antibody, clone HEK/1/85a recognizes the human CD195 cell surface antigen, a 45 kDa glycoprotein also known as CCR5. CD195 acts as a receptor for a number of chemokines including RANTES and eotaxin and serves as a co-receptor for the entry of HIV into cells. CD195 is expressed by a subset of T lymphocytes and by monocytes. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- CHO cells transfected with human CCR5
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised rats were fused with cell of the rat Y3 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | ![]() |
1/50 | 1/100 |
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 100μl fresh whole blood
References for CD195 antibody
-
Mueller, A. et al. (2002) Pathways for internalization and recycling of the chemokine receptor CCR5.
Blood 99 (3): 785-91. -
Pilch-Cooper, H.A. et al. (2011) Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5.
Blood 118: 1015-9. -
Ramirez, R. et al. (2006) Microinflammation in hemodialysis is related to a preactivated subset of monocytes.
Hemodial Int. 10 Suppl 1:S24-7. -
Liptrott, N.J. et al. (2009) The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC.
Br J Pharmacol. 156: 497-508. -
Bönsch, C. et al. (2015) Potent Anti-HIV Chemokine Analogs Direct Post-Endocytic Sorting of CCR5.
PLoS One 10 (4): e0125396. -
Holmannova, D. et al. (2017) Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression.
Perfusion. 32 (2): 141-50.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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