C3g antibody | 9

Rat anti Human C3g

Product Type
Monoclonal Antibody
Clone
9
Isotype
IgG1
Specificity
C3g

Product Code Applications Pack Size List Price Your Price Qty
MCA6162GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E IP 0.1 mg loader
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loader
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Rat anti Human C3g antibody, clone 9, (also known as clone YB2/90-5-20) recognizes a neoantigen in the C3g region of C3 and also recognizes the fragments iC3, iC3b and C3dg. There are 3 activation pathways within the complement system; the classical, lectin and alternative pathways. C3 is the key component of all 3, with all of them converging on C3, resulting in its activation and cleavage to the anaphylatoxin C3a and the opsonin C3b (Ricklin et al. 2016). C3b targets microbial cell surface receptors, enhancing phagocytosis (Fries et al. 1987). However, C3b is not stable in serum and is rapidly cleaved by factor I and a cofactor to form the more stable fragment iC3b (inactivated C3b) and C3f. iC3b is then slowly cleaved to form C3c, C3dg and C3f (Ricklin et al. 2016). Other proteases in vitro have been shown to cleave Cdg into C3d and C3g; however this has not been observed in vivo and thus is not thought to occur naturally (Lachmann et al. 1982).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunoprecipitation
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Synonyms
Complement C3g Fragment
UniProt
P01024
Entrez Gene
C3
GO Terms
GO:0005102 receptor binding
GO:0004866 endopeptidase inhibitor activity
GO:0005615 extracellular space
GO:0006954 inflammatory response
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0010575 positive regulation vascular endothelial growth factor production
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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