MCP-1 antibody
Rabbit anti Rat MCP-1
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- MCP-1
Rabbit anti Rat MCP-1 antibodyrecognizes rat monocyte chemo attractant protein-1 (MCP-1), also known as CCL-2. Rat MCP-1 is a chemokine of approximately 12 kDa, which plays an important role in the inflammatory response of blood monocytes and tissue macrophages. |
- Target Species
- Rat
- Product Form
- Purified IgG - lyophilized
- Reconstitution
- Reconstitute with 0.1ml distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.
N.B. For functional studies do not add sodium azide - Antiserum Preparation
- Antisera to rat MCP-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- Yes
- Immunogen
- Recombinant rat MCP-1.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml after reconstitution.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | 0.5 | 2.0ug/ml | |
Functional Assays | 4.0 | 6.0ug/ml | |
Immunohistology - Frozen | |||
Western Blotting | 0.1 | 0.2ug/ml |
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References for MCP-1 antibody
-
Schreiber, R.C. et al. (2001) Monocyte chemoattractant protein (MCP)-1 is rapidly expressed by sympathetic ganglion neurons following axonal injury.
Neuroreport. 12 (3): 601-6. -
Aharon-Hananel, G. et al. (2015) Antidiabetic Effect of Interleukin-1β Antibody Therapy Through β-Cell Protection in the Cohen Diabetes-Sensitive Rat.
Diabetes. 64 (5): 1780-5. -
Zhang, H. et al. (2016) Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy.
J Pain. 17 (7): 775-86. -
Tomas-Sanchez, C. et al. (2018) Prophylactic Zinc and Therapeutic Selenium Administration Increases the Antioxidant Enzyme Activity in the Rat Temporoparietal Cortex and Improves Memory after a Transient Hypoxia-Ischemia.
Oxid Med Cell Longev. 2018: 9416432. -
Rong, Y. et al. (2021) Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury.
J Neuroinflammation. 18 (1): 196.
- Synonyms
- CCL2
- RRID
- AB_2071792
- UniProt
- P14844
- Entrez Gene
- Ccl2
- GO Terms
- GO:0001666 response to hypoxia
- GO:0001938 positive regulation of endothelial cell proliferation
- GO:0005615 extracellular space
- GO:0005737 cytoplasm
- GO:0006874 cellular calcium ion homeostasis
- GO:0009612 response to mechanical stimulus
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0007179 transforming growth factor beta receptor signaling pathway
- View More GO Terms
- GO:0007568 aging
- GO:0008009 chemokine activity
- GO:0008201 heparin binding
- GO:0042493 response to drug
- GO:0009408 response to heat
- GO:0010332 response to gamma radiation
- GO:0014823 response to activity
- GO:0046677 response to antibiotic
- GO:0030593 neutrophil chemotaxis
- GO:0031100 organ regeneration
- GO:0031727 CCR2 chemokine receptor binding
- GO:0032496 response to lipopolysaccharide
- GO:0032570 response to progesterone stimulus
- GO:0033552 response to vitamin B3
- GO:0042466 chemokinesis
- GO:0043025 neuronal cell body
- GO:0043200 response to amino acid stimulus
- GO:0045471 response to ethanol
- GO:0048010 vascular endothelial growth factor receptor signaling pathway
- GO:0048246 macrophage chemotaxis
- GO:0048247 lymphocyte chemotaxis
- GO:0050806 positive regulation of synaptic transmission
- GO:0051384 response to glucocorticoid stimulus
- GO:0060137 maternal process involved in parturition
- GO:0070098 chemokine-mediated signaling pathway
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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