WDR5 antibody

Rabbit anti Human WDR5

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
WDR5

Product Code Applications Pack Size List Price Your Price Qty
AHP3113
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 ml loader
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loader
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Rabbit anti Human WDR5 antibody recognizes WD repeat-containing protein 5.

WDR5 is a member of the WD repeat protein family. WD repeats are thought to aid the formation of heterotrimeric or multiprotein complexes. WD repeat proteins play a role in a number of cellular processes, such as signal transduction, gene regulation, cell cycle progression and apoptosis (Patel-King and King, 2016). WDR5 expression is vital for vertebrate development. In human cells, WDR5 is also required for binding of the methyltransferase complex to the Lys4-di-methylated H3 tail and global H3 Lys4 tri-methylation (Wysocka et al. 2005).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human WDR5 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide within the C-terminal region of human WDR5
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P61964
Entrez Gene
WDR5
GO Terms
GO:0005515 protein binding
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0006350 transcription
GO:0043966 histone H3 acetylation
GO:0045449 regulation of transcription
GO:0048188 Set1C/COMPASS complex
GO:0051568 histone H3-K4 methylation
GO:0071339 MLL1 complex
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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