VEGF Receptor 2 antibody

Rabbit anti Human VEGF Receptor 2

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
VEGF Receptor 2

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AHP1327
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Rabbit anti Human VEGF receptor 2 antibody detects vascular endothelial growth factor receptor 2 (VEGFR2), a member of the tyrosine kinase family that plays an essential role in transducing the major signals for angiogenesis. VEGFR2 has also been implicated in embryonic development, wound healing, cell proliferation, migration and differentiation.

VEGFR2 is expressed mostly on vascular endothelial cells, and is expressed on a subpopulation of haematopoietic cells which might be the progenitor for endothelial cells.

Mutated forms of VEGFR2 have been implicated in cancer and diabetic retinopathy, where it results in pathological angiogenesis.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human VEGF receptor 2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.1%Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to an internal domain of human VEGF receptor 2, conjugated to Keyhole Limpet Hemocyanin (KLH).
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 10ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Breast carcinoma.

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References for VEGF Receptor 2 antibody

  1. Shibuya, M. (2006) Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.
    J Biochem Mol Biol. 39 (5): 469-78.
  2. Hjelmgren, O. et al. (2016) Increased Vascularization in the Vulnerable Upstream Regions of Both Early and Advanced Human Carotid Atherosclerosis.
    PLoS One. 11 (12): e0166918.

Synonyms
KDR
RRID
AB_906168
UniProt
P35968
Entrez Gene
KDR
GO Terms
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0019838 growth factor binding
GO:0005021 vascular endothelial growth factor receptor activity
GO:0005887 integral to plasma membrane
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0006468 protein phosphorylation
GO:0008360 regulation of cell shape
GO:0051879 Hsp90 protein binding
GO:0010595 positive regulation of endothelial cell migration
GO:0044419 interspecies interaction between organisms
GO:0050927 positive regulation of positive chemotaxis
GO:0051894 positive regulation of focal adhesion assembly
View more products with VEGF specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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