TGN46 antibody

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Rabbit anti Human TGN46

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP1586 IF* WB 0.1 ml
Rabbit anti Human TGN46 antibody recognizes Trans-Golgi network integral membrane protein 2, also known as TGN46, TGN38 homolog or Trans-Golgi network protein TGN51. TGN46 is a 480 amino acid ~110kDa single pass type I transmembrane glycoprotein associated with the trans golgi network membrane. TGN46 has been reported as being the best available marker for human trans-Golgi network.

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Primate
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Serum - liquid
Antiserum Preparation
Antisera to human TGN46 were raised by repeated immunisation of rabbits with highly purified recombinant human TGN46.
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Recombinant human TGN46.

Storage Information

Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
O43493 Related reagents
Entrez Gene
TGOLN2 Related reagents
Regulatory
For research purposes only

Applications of TGN46 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence 1 1/50 1/100
Western Blotting 1/500 1/000
  1. 1Fixation of tissues with 3% paraformaldehyde or methanol is recommended prior to using this antibody on immunofluorescence.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB

Useful Reagents Available

Description Product Code Pack Size Applications List Price Quantity
TidyBlot™ Western Blot Detection Reagent:HRP STAR209P 0.5 ml WB*

Product Specific References

References for TGN46 antibody

  1. Prescott, A.R. et al. (1997) Distinct compartmentalization of TGN46 and beta 1,4-galactosyltransferase in HeLa cells.
    Eur J Cell Biol. 72 (3): 238-46.
  2. Ponnambalam, S. et al. (1996) Primate homologues of rat TGN38: primary structure, expression and functional implications.
    J Cell Sci. 109 ( Pt 3): 675-85.
  3. Vuillier, F. et al. (2005) Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains.
    Blood. 105 (7): 2933-40.
  4. Cerqueira, C. et al. (2015) Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells.
    J Virol. 89 (14): 7038-52.
  5. Striebinger, H. et al. (2016) Subcellular Trafficking and Functional Relationship of the HSV-1 Glycoproteins N and M.
    Viruses. 8 (3): pii: E83.
  6. Sandri, C. et al. (2012) The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling.
    Cell Res. 22 (10): 1479-501.
  7. Aydin, I. et al. (2014) Large scale RNAi reveals the requirement of nuclear envelope breakdown for nuclear import of human papillomaviruses.
    PLoS Pathog. 10 (5): e1004162.