Rabbit anti Human TGN46 antibody recognizes Trans-Golgi network integral membrane protein 2, also known as TGN46, TGN38 homolog or Trans-Golgi network protein TGN51. TGN46 is a 480 amino acid ~110kDa single pass type I transmembrane glycoprotein associated with the trans golgi network membrane. TGN46 has been reported as being the best available marker for human trans-Golgi network.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to human TGN46 were raised by repeated immunisation of rabbits with highly purified recombinant human TGN46.
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
1% Bovine Serum Albumin
- Recombinant human TGN46.
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of TGN46 antibody
- 1Fixation of tissues with 3% paraformaldehyde or methanol is recommended prior to using this antibody on immunofluorescence.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
References for TGN46 antibody
Prescott, A.R. et al. (1997) Distinct compartmentalization of TGN46 and beta 1,4-galactosyltransferase in HeLa cells.
Eur J Cell Biol. 72 (3): 238-46.
Ponnambalam, S. et al. (1996) Primate homologues of rat TGN38: primary structure, expression and functional implications.
J Cell Sci. 109 ( Pt 3): 675-85.
Vuillier, F. et al. (2005) Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains.
Blood. 105 (7): 2933-40.
Cerqueira, C. et al. (2015) Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells.
J Virol. 89 (14): 7038-52.
Striebinger, H. et al. (2016) Subcellular Trafficking and Functional Relationship of the HSV-1 Glycoproteins N and M.
Viruses. 8 (3): pii: E83.
Sandri, C. et al. (2012) The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling.
Cell Res. 22 (10): 1479-501.
Aydin, I. et al. (2014) Large scale RNAi reveals the requirement of nuclear envelope breakdown for nuclear import of human papillomaviruses.
PLoS Pathog. 10 (5): e1004162.
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