TEM7 antibody

Rabbit anti TEM7

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
TEM7

Product Code Applications Pack Size List Price Your Price Qty
AHP1624
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SDS Safety Datasheet SDS
P * WB 0.1 mg loader
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Rabbit anti Human TEM7 antibody recognises human Tumour endothelial marker 7, also known as TEM7, a 55.8 kDa protein belonging to the plexin family.

TEM7 is strongly expressed in endothelial cells from colorectal cancer and from primary cancers of the lung, liver, brain, breast and pancreas. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.

There appear to be at least four isoforms of TEM7 which include membrane bound, secreted and intracellular forms. TEM7 is not detectable in endothelial cells from normal tissues.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human TEM7 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
A peptide corresponding to a 16 amino acid sequence from near the center of human TEM7.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 2.5ug/ml
Western Blotting 0.5 1.0ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Mouse liver
Western Blotting
AHP1624 detects a band of approximately 56kDa in rat liver cell lysates.

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Synonyms
TEM3
RRID
AB_2166226
UniProt
Q8IUK5
Entrez Gene
PLXDC1
GO Terms
GO:0001525 angiogenesis
GO:0016021 integral to membrane
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005923 tight junction
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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