TACR3 antibody

Rabbit anti TACR3

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
TACR3

Product Code Applications Pack Size List Price Your Price Qty
AHP1492
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Rabbit anti Human TACR3 antibody recognizes human TACR3 otherwise known as NK3 Receptor (NK3R), a 52.2 kDa multi-pass membrane protein belonging to the G-protein coupled receptor 1 family.

TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system, and it is likely that these signals lead to the release of vasopressin and oxytocin into the circulation. TACR3 is involved in learning and memory (Zhang et al. 2020).

Rabbit anti Human TACR3 antibody ( AHP1492) does not recognize NK1R or NK2R.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human TACR3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
An 18 amino acid peptide from near the centre of human TACR3.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 5ug/ml
Western Blotting 0.5 1.0ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human brain
Western Blotting
AHP1492 detects a band of approximately 46kDa in RAW264.7 cell lysates.

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Further Reading

  1. Haley, G.E. & Flynn, F.W. (2007) Tachykinin NK3 receptor contribution to systemic release of vasopressin and oxytocin in response to osmotic and hypotensive challenge.
    Am J Physiol Regul Integr Comp Physiol. 293 (2): R931-7.
  2. Ding, Y.Q. et al. (1999) Neurokinin B receptor (NK3)-containing neurons in the paraventricular and supraoptic nuclei of the rat hypothalamus synthesize vasopressin and express Fos following intravenous injection of hypertonic saline.
    Neuroscience. 91 (3): 1077-85.
  3. Maggi, C.A. (1995) The mammalian tachykinin receptors.
    Gen Pharmacol. 26 (5): 911-44.
  4. Nakajima, Y. et al. (1992) Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic AMP cascades in transfected Chinese hamster ovary cells.
    J Biol Chem. 267 (4): 2437-42.

Synonyms
NK3R
RRID
AB_2200923
UniProt
P29371
Entrez Gene
TACR3
GO Terms
GO:0004995 tachykinin receptor activity
GO:0005887 integral to plasma membrane
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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