PRMT2 antibody
Rabbit anti Human PRMT2
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- PRMT2
Antibody Quality and Performance Guarantee
| Rabbit anti Human PRMT2 antibody recognizes protein arginine N-methyltransferase 2. PRMT2 methylates arginyl residues in proteins such as STAT3, FBL, histone H4 and functions as a coactivator of androgen receptor (AR)-mediated and estrogen receptor (ER)-mediated transactivation (Qi et al. 2002, Meyer et al. 2007). PRMT2 may inhibit NF-kappa-B transcription and promote apoptosis involved in growth regulation (Ganesh et al. 2006). In humans, the C-terminal domain of pol II (CTD) comprises 52 repeats of the consensus heptapeptide Tyr1/Ser2/Pro3/Thr4/Ser5/Pro6/Ser7 that is phosphorylated by several kinases during transcription (Zaborowska et al. 2016). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human PRMT2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.035% Sodium Azide (NaN3)
30% Glycerol - Carrier Free
- Yes
- Immunogen
- A peptide within the N-terminal region of human PRMT2
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunofluorescence |  |
1/2000 | |
| Western Blotting | |
1/500 | 1/2500 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P55345
- Entrez Gene
- PRMT2
- GO Terms
- GO:0003713 transcription coactivator activity
- GO:0005829 cytosol
- GO:0004871 signal transducer activity
- GO:0005634 nucleus
- GO:0006479 protein methylation
- GO:0006917 induction of apoptosis
- GO:0008168 methyltransferase activity
- GO:0016481 negative regulation of transcription
- GO:0046966 thyroid hormone receptor binding
- View More GO Terms
- GO:0030331 estrogen receptor binding
- GO:0032088 negative regulation of NF-kappaB transcription factor activity
- GO:0033142 progesterone receptor binding
- GO:0042803 protein homodimerization activity
- GO:0042974 retinoic acid receptor binding
- GO:0042975 peroxisome proliferator activated receptor binding
- GO:0050681 androgen receptor binding
- GO:0060765 regulation of androgen receptor signaling pathway
- GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
AHP3098
160756
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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