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PRMT2 antibody

Rabbit anti Human PRMT2

Product Type
Polyclonal Antibody
Polyclonal IgG

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Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
IF WB 0.1 ml loader
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Rabbit anti Human PRMT2 antibody recognizes protein arginine N-methyltransferase 2.

PRMT2 methylates arginyl residues in proteins such as STAT3, FBL, histone H4 and functions as a coactivator of androgen receptor (AR)-mediated and estrogen receptor (ER)-mediated transactivation (Qi et al. 2002, Meyer et al. 2007). PRMT2 may inhibit NF-kappa-B transcription and promote apoptosis involved in growth regulation (Ganesh et al. 2006). In humans, the C-terminal domain of pol II (CTD) comprises 52 repeats of the consensus heptapeptide Tyr1/Ser2/Pro3/Thr4/Ser5/Pro6/Ser7 that is phosphorylated by several kinases during transcription (Zaborowska et al. 2016).

Target Species
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human PRMT2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
A peptide within the N-terminal region of human PRMT2
For research purposes only
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence 1/2000
Western Blotting 1/500 1/2500
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Entrez Gene
GO Terms
GO:0003713 transcription coactivator activity
GO:0005829 cytosol
GO:0004871 signal transducer activity
GO:0005634 nucleus
GO:0006479 protein methylation
GO:0006917 induction of apoptosis
GO:0008168 methyltransferase activity
GO:0016481 negative regulation of transcription
GO:0046966 thyroid hormone receptor binding
GO:0030331 estrogen receptor binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033142 progesterone receptor binding
GO:0042803 protein homodimerization activity
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0050681 androgen receptor binding
GO:0060765 regulation of androgen receptor signaling pathway
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle



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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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