PITX2 antibody

Rabbit anti Human PITX2

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
PITX2

Product Code Applications Pack Size List Price Your Price Qty
AHP3095
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 ml loader
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loader
Search for Batch Specific Datasheets

Rabbit anti Human PITX2 antibody recognizes pituitary homeobox 2, also known as paired-like homeodomain transcription factor 2.

PITX2 is a member of the RIEG/PITX homeobox family and functions as a transcription factor (Logan et al. 1998). PITX2 regulates the expression of procollagen lysyl hydroxylase; involved in the development of teeth, eyes, and abdominal organs. Mutations in the PTIX2 gene have been linked to Axenfeld-Rieger syndrome (ARS) (Héon et al. 1995). Aberrant levels of PITX2 have also been observed in cancers like thyroid, ovarian, and colon cancer (Huang et al. 2010) (Fung et al. 2012) (Hirose et al. 2011).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human PITX2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide within the N-terminal region of human PITX2
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
Q99697
Entrez Gene
PITX2
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005667 transcription factor complex
GO:0006355 regulation of transcription, DNA-dependent
GO:0007368 determination of left/right symmetry
GO:0009887 organ morphogenesis
GO:0008134 transcription factor binding
GO:0030528 transcription regulator activity
GO:0043565 sequence-specific DNA binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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