Lymphotactin antibody

Rabbit anti Human Lymphotactin

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Lymphotactin

Product Code Applications Pack Size List Price Your Price Qty
AHP364G
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SDS Safety Datasheet SDS
E FN P * WB 0.1 mg loader
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Rabbit anti Human Lymphotactin antibody recognizes human Lymphotactin, otherwise known as XCL1, the only member of the C-chemokine family identified so far. Unlike other members of the chemokine superfamily, Lymphotactin uniquely acts as a chemoattractant for lymphocytes, but not monocytes or neutrophils, suggesting an important regulatory role in lymphocyte trafficking and inflammation.

Lymphotactin, shown to signal through chemokine XC receptor 1 (XCR1), is detected at the highest level in the spleen and at low levels in the lungs, small intestine and colon, and is abundantly and selectively expressed by activated T cells, in particular CD8+ T cells, and is also produced by NK cells.

Target Species
Human
Product Form
Purified IgG - lyophilized
Reconstitution
Reconstitute with 0.1 ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not use azide.
Antiserum Preparation
Antisera to human lymphotactin were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Carrier Free
Yes
Immunogen
Recombinant human lymphotactin.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml after reconstitution
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.

This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 0.5 2.0ug/ml
Functional Assays 1.7 3.0ug/ml
Immunohistology - Paraffin 1 0.5ug/ml
Western Blotting 0.1 0.2ug/ml
  1. 1 This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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References for Lymphotactin antibody

  1. Blaschke, S. et al. (2003) Expression of activation-induced, T cell-derived, and chemokine-related cytokine/lymphotactin and its functional role in rheumatoid arthritis.
    Arthritis Rheum. 48: 1858-72.

Further Reading

  1. Kennedy, J. et al. (1995) Molecular cloning and functional characterization of human lymphotactin.
    J Immunol. 155 (1): 203-9.

Synonyms
XCL1
RRID
AB_2217050
UniProt
P47992
Entrez Gene
XCL1
GO Terms
GO:0007165 signal transduction
GO:0005615 extracellular space
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0008009 chemokine activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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