KDM4B antibody

Rabbit anti Human KDM4B

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
KDM4B

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AHP3078
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Rabbit anti Human KDM4B antibody recognizes lysine-specific demethylase 4B, also known as JMJD2B.

KDM4B is a member of the alpha-ketoglutarate-dependent hydroxylase superfamily of enzymes. Alpha-ketoglutarate-dependent hydroxylases catalyse a wide range of reactions, including hydroxylation, demethylation and desaturation (Flashman and Schofield, 2007, Hausinger, 2004). KDM4B functions as a histone demethylase and is involved in the regulation of endothelial-to-mesenchymal transition (Glaser et al. 2020). KDM4B also forms a complex with MLL2 and acts as a co-factor of ERa-mediated transcription (Kawazu et al. 2011).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human KDM4B was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide within the C-terminal region of human KDM4B
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence 1/2000
Immunoprecipitation 10 µl per IP
Western Blotting 1/500 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Synonyms
Lysine-Specific Demethylase 4B
UniProt
O94953
Entrez Gene
KDM4B
GO Terms
GO:0003676 nucleic acid binding
GO:0005634 nucleus
GO:0055114 oxidation-reduction process
GO:0006350 transcription
GO:0008270 zinc ion binding
GO:0016568 chromatin modification
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0045449 regulation of transcription
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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