JMJD6 antibody

Rabbit anti Human JMJD6

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
JMJD6

Product Code Applications Pack Size List Price Your Price Qty
AHP3079
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 ml loader
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Rabbit anti Human JMJD6 antibody recognizes bifunctional arginine demethylase and lysyl-hydroxylase JMJD6.

JMJD6 is a member of the alpha-ketoglutarate-dependent hydroxylase superfamily located in the nucleus of eukaryotic cells (Vandivier et al. 2002). JMJD6 plays a role in phagocytosis of apoptotic cells and may function as protein hydroxylase or a histone demethylase and play a role in angiogenesis (Boeckel et al. 2011). Aberrant levels of JMJD6 have also been observed in some breast cancers and may be associated with increased tumor aggressiveness and metastasis (Aprelikova et al. 2016).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human JMJD6 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide within the N-terminal region of human JMJD6
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
Q6NYC1
Entrez Gene
JMJD6
GO Terms
GO:0046872 metal ion binding
GO:0005634 nucleus
GO:0055114 oxidation-reduction process
GO:0006350 transcription
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0042802 identical protein binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
GO:0033746 histone demethylase activity (H3-R2 specific)
GO:0033749 histone demethylase activity (H4-R3 specific)
GO:0045449 regulation of transcription
GO:0048024 regulation of nuclear mRNA splicing, via spliceosome
GO:0070078 histone H3-R2 demethylation
GO:0070079 histone H4-R3 demethylation
GO:0070815 peptidyl-lysine 5-dioxygenase activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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