JAK2 (pTyr1007) antibody
Rabbit anti JAK2 (pTyr1007)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- JAK2 (pTyr1007)
Antibody Quality and Performance Guarantee
| Rabbit anti JAK2 (pTyr1007) antibody recognizes janus kinase 2 (JAK2), also known as tyrosine-protein kinase JAK2, when phosphorylated at tyrosine 1007. JAK2 is a non-receptor tyrosine protein kinase involved in stem cell maintenance, haematopoiesis, and inflammation through its involvement in the JAK/STAT signaling pathway. Autophosphorylation of JAK2 at tyrosine 1007 activates JAK2 and the JAK/STAT signaling pathway. (Lucet et al. 2006). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to JAK2 (pTyr1007) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.05% ProClin 300
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding tyrosine 1007 of human JAK2
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- ProClin is a trademark of The Dow Chemical Company (“Dow”) or an affiliated company of Dow.
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/200 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Further Reading
-
Lucet, I.S. et al. (2006) The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.
Blood. 107 (1): 176-83.
- UniProt
- O60674
- Entrez Gene
- JAK2
- GO Terms
- GO:0042393 histone binding
- GO:0007596 blood coagulation
- GO:0005829 cytosol
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005131 growth hormone receptor binding
- GO:0005524 ATP binding
- GO:0005856 cytoskeleton
- GO:0006928 cellular component movement
- GO:0007498 mesoderm development
- View More GO Terms
- GO:0012505 endomembrane system
- GO:0046677 response to antibiotic
- GO:0030218 erythrocyte differentiation
- GO:0035401 histone kinase activity (H3-Y41 specific)
- GO:0042169 SH2 domain binding
- GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
- GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
- GO:0042977 activation of JAK2 kinase activity
- GO:0046777 protein autophosphorylation
- GO:0060333 interferon-gamma-mediated signaling pathway
- GO:0060334 regulation of interferon-gamma-mediated signaling pathway
- GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
AHP2639
141596
155451
166790
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