Rabbit anti JAK2 (pTyr1007) antibody
recognizes janus kinase 2 (JAK2), also known as tyrosine-protein kinase JAK2, when phosphorylated at tyrosine 1007. JAK2 is a non-receptor tyrosine protein kinase involved in stem cell maintenance, haematopoiesis, and inflammation through its involvement in the JAK/STAT signaling pathway.
Autophosphorylation of JAK2 at tyrosine 1007 activates JAK2 and the JAK/STAT signaling pathway. (Lucet et al. 2006
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to JAK2 (pTyr1007) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding tyrosine 1007 of human JAK2
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
non-membrane spanning protein tyrosine kinase activity
growth hormone receptor binding
cellular component movement
response to antibiotic
histone kinase activity (H3-Y41 specific)
SH2 domain binding
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
activation of JAK2 kinase activity
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of JAK2 (pTyr1007) antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Lucet, I.S. et al. (2006) The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.
Blood. 107 (1): 176-83.
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