FOXM1 antibody

Rabbit anti Human FOXM1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
FOXM1

Product Code Applications Pack Size List Price Your Price Qty
AHP3041
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SDS Safety Datasheet SDS
WB 0.1 ml loader
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loader
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Rabbit anti Human FOXM1 antibody recognizes forkhead box protein M1, also known as M-phase phosphoprotein 2 or MPM-2 reactive phosphoprotein 2.

FOXM1 is a member of the FOX family of transcription factors (Korver et al. 1997) and plays a key role in cell cycle progression, maintenance of chromosomal segregation and genomic stability (Laoukili et al. 2005). In humans, aberrant levels of FOXM1 have been observed in a number of cancers, including basal cell carcinoma and cancers of the liver (Kalinichenko et al. 2004), lung (Kim et al. 2006) and colon (Douard et al. 2006).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human FOXM1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide within the C-terminal region of human FOXM1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
Q08050
Entrez Gene
FOXM1
GO Terms
GO:0005515 protein binding
GO:0001558 regulation of cell growth
GO:0001570 vasculogenesis
GO:0001889 liver development
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003702 RNA polymerase II transcription factor activity
GO:0003704 specific RNA polymerase II transcription factor activity
GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
GO:0005737 cytoplasm
GO:0005667 transcription factor complex
GO:0006366 transcription from RNA polymerase II promoter
GO:0007049 cell cycle
GO:0009790 embryo development
GO:0007389 pattern specification process
GO:0009888 tissue development
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell proliferation
GO:0008301 DNA bending activity
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010843 promoter binding
GO:0016563 transcription activator activity
GO:0016566 specific transcriptional repressor activity
GO:0019904 protein domain specific binding
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0042127 regulation of cell proliferation
GO:0046578 regulation of Ras protein signal transduction
GO:0051090 regulation of transcription factor activity
GO:0071156 regulation of cell cycle arrest
GO:0080010 regulation of oxygen and reactive oxygen species metabolic process
GO:0090344 negative regulation of cell aging
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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