FOXL2 antibody
Rabbit anti Human FOXL2
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- FOXL2
Antibody Quality and Performance Guarantee
| Rabbit anti Human FOXL2 antibody recognizes forkhead box protein L2. FOXL2 is a 39 kDa transcription factor that belongs to the forkhead box (FOX) superfamily. This family of proteins is characterized by the forkhead box/winged-helix DNA-binding domain. FOXL2 plays an important role in the development and function of ovaries and inhibits the formation of testes via suppression of SOX9 expression (Yang et al. 2017). FOXL2 expression levels have been shown to play a role in the development of a number of pathologies, including adult granulosa cell tumors and endometriosis (Leung et al. 2016) (Governini et al. 2014). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human FOXL2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.035% Sodium Azide (NaN3)
30% Glycerol - Carrier Free
- Yes
- Immunogen
- A peptide within the N-terminal region of human FOXL2
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 | 1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P58012
- Entrez Gene
- FOXL2
- GO Terms
- GO:0001541 ovarian follicle development
- GO:0002074 extraocular skeletal muscle development
- GO:0003690 double-stranded DNA binding
- GO:0003704 specific RNA polymerase II transcription factor activity
- GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
- GO:0005667 transcription factor complex
- GO:0006309 DNA fragmentation involved in apoptotic nuclear change
- GO:0006917 induction of apoptosis
- GO:0007389 pattern specification process
- View More GO Terms
- GO:0008134 transcription factor binding
- GO:0008301 DNA bending activity
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010843 promoter binding
- GO:0016563 transcription activator activity
- GO:0016566 specific transcriptional repressor activity
- GO:0019101 female somatic sex determination
- GO:0030331 estrogen receptor binding
- GO:0031624 ubiquitin conjugating enzyme binding
- GO:0042703 menstruation
- GO:0043028 caspase regulator activity
- GO:0043280 positive regulation of caspase activity
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
- GO:0048048 embryonic eye morphogenesis
- GO:0051090 regulation of transcription factor activity
- GO:0060026 convergent extension
AHP3040
160798
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