FOXL2 antibody

Rabbit anti Human FOXL2

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
FOXL2

Product Code Applications Pack Size List Price Your Price Qty
AHP3040
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SDS Safety Datasheet SDS
WB 0.1 ml loader
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loader
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Rabbit anti Human FOXL2 antibody recognizes forkhead box protein L2.

FOXL2 is a 39 kDa transcription factor that belongs to the forkhead box (FOX) superfamily. This family of proteins is characterized by the forkhead box/winged-helix DNA-binding domain. FOXL2 plays an important role in the development and function of ovaries and inhibits the formation of testes via suppression of SOX9 expression (Yang et al. 2017). FOXL2 expression levels have been shown to play a role in the development of a number of pathologies, including adult granulosa cell tumors and endometriosis (Leung et al. 2016) (Governini et al. 2014).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human FOXL2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide within the N-terminal region of human FOXL2
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P58012
Entrez Gene
FOXL2
GO Terms
GO:0001541 ovarian follicle development
GO:0002074 extraocular skeletal muscle development
GO:0003690 double-stranded DNA binding
GO:0003704 specific RNA polymerase II transcription factor activity
GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
GO:0005667 transcription factor complex
GO:0006309 DNA fragmentation involved in apoptotic nuclear change
GO:0006917 induction of apoptosis
GO:0007389 pattern specification process
GO:0008134 transcription factor binding
GO:0008301 DNA bending activity
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010843 promoter binding
GO:0016563 transcription activator activity
GO:0016566 specific transcriptional repressor activity
GO:0019101 female somatic sex determination
GO:0030331 estrogen receptor binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0042703 menstruation
GO:0043028 caspase regulator activity
GO:0043280 positive regulation of caspase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048048 embryonic eye morphogenesis
GO:0051090 regulation of transcription factor activity
GO:0060026 convergent extension
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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