EHMT1 antibody

Rabbit anti Human EHMT1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
EHMT1

Product Code Applications Pack Size List Price Your Price Qty
AHP3039
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
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loader
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Rabbit anti Human EHMT1 antibody recognizes euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP).

EHMT1 shares an evolutionary conserved SET domain with G9A, a histone methyltransferase enzyme (Shinkai and Tachibana, 2011). EHMT1 and G9A function exclusively as a heteromeric complex (Tachibana et al. 2005). G9A and EHMT1 also share a region containing ankryin repeats, involved in protein-protein interactions. The G9A/EHMT1 complex is able to methylate a wide range of non-histone proteins including transcription factors such as p53. As a result of their non-histone protein methyltransferase activity, both G9A and EHMT1 play a role in a wide range of cellular processes including cellular response to environmental stimuli, the establishment and maintenance of cell identity, and cell cycle regulation (Ling et al. 2012).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human EHMT1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein A.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide derived from the N-terminal region of human EHMT1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1 µg/ml 2 µg/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
Q9H9B1
Entrez Gene
EHMT1
GO Terms
GO:0002039 p53 binding
GO:0005634 nucleus
GO:0005694 chromosome
GO:0006306 DNA methylation
GO:0009790 embryo development
GO:0008270 zinc ion binding
GO:0018026 peptidyl-lysine monomethylation
GO:0018027 peptidyl-lysine dimethylation
GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0046976 histone methyltransferase activity (H3-K27 specific)
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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