Dopamine Transporter antibody

Rabbit anti Human Dopamine Transporter (C-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Dopamine Transporter
Region
(C-TERMINAL)

Product Code Applications Pack Size List Price Your Price Qty
AHP932
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SDS Safety Datasheet SDS
C WB 0.1 ml loader
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Rabbit anti Human dopamine transporter antibody recognizes an epitope within the C-terminal region of dopamine transporter (DAT), also known as solute carrier family 6.

DAT is principally expressed in the presynaptic membrane of dopaminergic nerve terminals, where it mediates the rapid removal of dopamine from the synaptic cleft after neuronal stimulation. As such, DAT plays an important role in regulating the availability of dopamine in the synaptic cleft and thus in modulating the physiological functions of dopamine.

The reuptake of dopamine by DAT is inhibited by psychostimulants such as cocaine and amphetamine.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Monkey
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human dopamine transporter (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
10mM HEPES pH7.5
150mM NaCl
Preservative Stabilisers
0.09%Sodium Azide
0.01%Bovine Serum Albumin
50%Glycerol
Immunogen
Keyhole limpet haemocyanin conjugated synthetic peptide corresponding to the C-terminus region (CT) of human dopamine transporter.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen 1/1000
Western Blotting 1/1000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP932 detects a band of approximately 88kDa in human caudate cell lysates.

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References for Dopamine Transporter antibody

  1. Mozley, L.H. et al. (2001) Striatal dopamine transporters and cognitive functioning in healthy men and women.
    Am J Psychiatry. 158 (9): 1492-9.

RRID
AB_2286179
UniProt
Q01959
Entrez Gene
SLC6A3
GO Terms
GO:0042136 neurotransmitter biosynthetic process
GO:0005887 integral to plasma membrane
GO:0005737 cytoplasm
GO:0008219 cell death
GO:0030424 axon
GO:0043025 neuronal cell body
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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