CtBP2 antibody

Rabbit anti Human CtBP2

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
CtBP2

Product Code Applications Pack Size List Price Your Price Qty
AHP3034
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
Ch WB 0.1 ml loader
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loader
Search for Batch Specific Datasheets

Rabbit anti Human CtBP2 antibody recognizes C-terminal-binding protein 2.

CtBP2 is a protein that in humans is encoded by the CtBP2 gene (Turner and Crossley, 2001). In mammals, C-terminal binding proteins (CtBP1 and CtBP2) function as transcriptional corepressors (Shi et al. 2004). CtBPs bind to many different DNA-binding proteins as well as other co-repressors, such as friend of GATA (Fog), that are themselves bound to DNA-binding proteins (Fox et al. 1999). CtBPs are also able to dimerize and multimerize to bridge larger transcriptional complexes and function as scaffold proteins that enable the assembly of gene repression complexes. In mammals, there are two distinct isoforms of CtBP2; a 56 kDa isoform that functions as a transcriptional repressor, and a 106 kDa isoform that is a major component of specialized synapses known as synaptic ribbons.

Rabbit anti human CtBP2 antibody recognizes both isoforms 1 and 2 of CtBP2.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human CtBP2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.035% Sodium Azide (NaN3)
30% Glycerol
Carrier Free
Yes
Immunogen
A peptide in the C-terminal region of human CtBP2
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Chromatin Immunoprecipitation 10 µl per ChIP
Western Blotting 1/500 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P56545
Entrez Gene
CTBP2
GO Terms
GO:0005515 protein binding
GO:0055114 oxidation-reduction process
GO:0006350 transcription
GO:0019079 viral genome replication
GO:0008285 negative regulation of cell proliferation
GO:0016564 transcription repressor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0017053 transcriptional repressor complex
GO:0030054 cell junction
GO:0045202 synapse
GO:0050872 white fat cell differentiation
GO:0051287 NAD binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products